Now showing items 11-20 of 57
Delta opioid receptor mRNA distribution in the brain: Comparison to delta receptor binding and proenkephalin mRNA
(Elsevier, 1993)
The recent cloning of the mouse delta opioid receptor (Evans et al., 1992; Kieffer et al., 1992) has demonstrated it to be a member of the seven transmembrane G-protein coupled family of neurotransmitter receptors. The ...
[beta]-Endorphin processing and cellular origins in rat spinal cord
(Elsevier, 1992-11)
While enkephalin and dynorphin peptides have been well characterized in the spinal cord, the cellular localization of [beta]-endorphin ([beta]E) and the processing of pro-opiomelanocortin (POMC) to [beta]E and other ...
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain
(Elsevier, 1984-12)
To determine whether opioid peptide-receptor pharmacological associations found in vitro (e.g., enkephalin-[delta], dynorphin-[kappa]) predict anatomical relationships in situ, immunocytochemical and receptor autoradiographic ...
Inhibition of opiate tolerance by non-competitive receptor antagonists
(Elsevier, 1994-01-07)
Our laboratory and others have previously reported that the non-competitive (NMDA) receptor antagonist, MK-801, interferes with the development of tolerance to the analgesic effects of morphine. The present studies were ...
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques
(Elsevier, 1992-02)
D1, a subtype of the dopamine receptors, is widely distributed in the nervous system and has been shown to be positively coupled to adenylate cyclase. Using a combination of in vitro receptor autoradiographic and in situ ...
Anatomy of CNS opioid receptors
(Elsevier, 1988)
There is a wide body of evidence to suggest the existence of at least three distinct opioid receptor types in the CNS, referred to as [mu], [delta], and [kappa]. This paper reviews some of the findings that have led to ...
The preferential release of beta-endorphin from the anterior pituitary lobe by Corticotropin Releasing Factor (CRF)
(Elsevier, 1986)
Although a number of investigators have shown that release of ACTH is accompanied by the release of Beta-endorphin ([beta]-End) and Beta-lipotropin ([beta]-LPH), the proportion of the latter two peptides released with ...
Steady state levels of pro-dynorphin-related end products in the striatum and substantia nigra of the adult rhesus monkey
(Elsevier, 1985)
Analysis of an acid extract of the striatum of the rhesus monkey revealed that the molar ratio of dynorphin A(1-8)-sized material and dynorphin (A(1-17)-sized material is approximately 1:1. In addition, the molar ratios ...
Paradoxical effect of corticosteroids on pituitary ACTH/[beta]-endorphin release in stressed animals
(Elsevier, 1988)
We have previously demonstrated a number of changes in the anterior lobe proopiomelanocortin (POMC) system in chronically stressed rats. The purpose of the present experiments was to investigate whether chronically stressed ...
Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations
(Elsevier, 1980)
Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of ...