Now showing items 21-30 of 56
Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD
(Springer-Verlag, 2004-03)
Exaggerated acoustic startle is a prominent symptom of post-traumatic stress disorder (PTSD); however, its physiological basis is not well understood, and there are few available treatments. Neurobiological research has ...
Euphoriant effects of nicotine in smokers
(Springer-Verlag, 1992-09)
Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, ...
Nicotine may relieve symptoms of Parkinson's disease
(Springer-Verlag, 1994-09)
Two elderly patients with Parkinson's disease were treated with nicotine gum and patch. Reliable changes in symptomatology were noted, using a single-subject, placebo-control reversal design. Improvement was associated ...
Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level
(Springer-Verlag, 1987-09)
Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking topography (e.g., puff rate, puff duration), expired carbon ...
Distribution of D2 dopamine receptor mRNA in the primate brain
(Elsevier, 1991)
1. The distribution of the messenger RNA (mRNA) encoding the D2dopamine receptor has been mapped in the monkey brain by hybridization.2. Using [35s]-labelled riboprobes corresponding to the region of the D2 dopamine ...
Comparison of acute and chronic lithium treatment on 3 H-norepinephrine uptake by rat brain slices
(Springer-Verlag, 1980-01)
The effects of lithium chloride, given IP in high (2.5–15 mEq/kg) and low (1.25 mEq/kg) doses twice daily, upon 3 H-norepinephrine uptake and retention were examined with slices from four regions of the rat brain, namely ...
Analysis of opioid and non-opioid end products of pro-dynorphin in the substantia nigra of the rat
(Elsevier, 1985-02)
The substantia nigra is among the richest pro-dynorphin terminal field regions in the rat brain. We therefore contrasted processing in this area to the known processing in the posterior pituitary. Fractionation of acid ...
In Vitro release of hypothalamic [beta]-endorphin [beta]E by arginine vasopressin, corticotropin-releasing hormone and 5-hydroxytryptamine: Evidence for release of opioid active and inactive [beta]E forms
(Elsevier, 1990-05)
The aims of the present experiments were: 1) to test whether substances which modulate beta-endorphin-immunoreactive [beta]E-ir release from the pituitary gland might act similarly in hypothalamic tissue; and 2) to further ...