Now showing items 31-40 of 67
Tritiated ethylketocyclazocine binding in rat brain: Differential distribution of binding sites across brain regions
(Elsevier, 1982-09)
In rat brain, 3H-EKC shows a relative regional distribution of binding which parallels that of 3H-morphine. Dynorphin(1-13) has a pattern similar to morphine and dissimilar to EKC in displacing the three labels. Dynorphin(1-13) ...
Characterization of the forms of [beta]-endorphin and [alpha]-MSH in the caudal medulla of the rat and guinea pig
(Elsevier, 1986-07-09)
The post-translational processing of pro-opiomelanocortin (POMC) in brain remains controversial. Classically, there was thought to be a single cell group in the arcuate nucleus with long projections through limbic structures. ...
Analysis of opioid and non-opioid end products of pro-dynorphin in the substantia nigra of the rat
(Elsevier, 1985-02)
The substantia nigra is among the richest pro-dynorphin terminal field regions in the rat brain. We therefore contrasted processing in this area to the known processing in the posterior pituitary. Fractionation of acid ...
[3H] dynorphin binding to guinea pig and rat brain
(Elsevier, 1983)
[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity ...
In Vitro release of hypothalamic [beta]-endorphin [beta]E by arginine vasopressin, corticotropin-releasing hormone and 5-hydroxytryptamine: Evidence for release of opioid active and inactive [beta]E forms
(Elsevier, 1990-05)
The aims of the present experiments were: 1) to test whether substances which modulate beta-endorphin-immunoreactive [beta]E-ir release from the pituitary gland might act similarly in hypothalamic tissue; and 2) to further ...
[kappa]1 Receptor mRNA Distribution in the Rat CNS: Comparison to [kappa] Receptor Binding and Prodynorphin mRNA
(Elsevier, 1994-04)
Three opioid receptor types have been identified in the CNS and periphery that are referred to as [mu], [delta], and [kappa]. The present study examines the mRNA distribution of the [kappa]1 receptor in the rat brain and ...
Cloning and pharmacological characterization of a rat [mu] opioid receptor
(Elsevier, 1993-11)
We have isolated a rat cDNA clone that displays 75% amino acid homology with the mouse [delta] and rat [kappa] opioid receptors. The cDNA (designated pRMuR-12) encodes a protein of 398 amino acids comprising, in part, seven ...
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms : Cleavage at a single arginine residue
(Elsevier, 1994-01-03)
Processing of rat prodynorphin (proDyn) by the mouse prohormone convertase PCI was investigated. Recombinant vaccinia virus vectors were used to coexpress proDyn and PC1 in rat PC12 pheochromocytoma and mouse AtT-20 ...
Dynorphin (1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effects
(Elsevier, 2006-04-07)
Dynorphin and an opiate-inactive fragment des-Tyr-dynorphin produced similar effects on EEG, motor function and hippocampal unit firing. Naloxone had no effect on the actions of dynorphin in these systems and dynorphin ...