Now showing items 11-13 of 13
A Less Toxic Heparin Antagonist—Low Molecular Weight Protamine
(Kluwer Academic Publishers-Plenum Publishers; MAIK “Nauka/Interperiodica” ; Springer Science+Business Media, 2003-01)
A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the ...
Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-05)
Purpose. The purpose of this work was to determine the jejunal permeability of cyclosporin A (CsA) in humans and whether formulation variables modulate the effects of P-glycoprotein (P-gp) on the permeability of CsA in ...
A Fluorescent hPept1 Transporter Substrate for Uptake Screening
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-11)
Purpose. To synthesize fluorescent analogues of hPept1 substrates, FITC-Val-OCH 3 , Lys-FITC-OH, and Lys-FITC-OCH 3 , and to characterize their hPept1 transporter-mediated uptake.