Now showing items 31-40 of 71
The Relation between Adsorption of Additives and Crystal Growth Rate of L-Alanine
(Elsevier, 1993-04)
The growth kinetics of L-alanine from solution in the presence and absence of L-phenylalanine and L-leucine has been studied. L-Alanine crystal growth, from crystal size distribution measurements, is independent of the ...
Modeling drug release from dynamically swelling poly(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels
(Elsevier, 1990-05)
Drug release from a swelling hydrogel matrix is a complicated process where diffusion of drug molecules is coupled to the swelling kinetics. The swelling influences the diffusional flux of drug molecules by increasing the ...
DNA polymerase in nuclei isolated from herpes simplex virus type-2-infected cells. Characterization of the reaction product and inhibition by substrate analogs
(Elsevier, 1984-02-24)
Nuclei isolated from herpes simplex virus (HSV) type 2-infected KB cells were examined for their capacity to serve as an in situ source of herpes DNA polymerase. In contrast to purified enzymes with added template, approx. ...
Studies in vitro with ICI 174, 864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO)
(Elsevier, 1985-02)
The interactions of a proposed, selective delta receptor antagonist (ICI 174, 864) and selective agonists at mu and delta receptors, [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO) and [D-Pen2, D-Pen5]-enkephalin (DPDPE), ...
Axial selectivity of 1,2-nucleophilic additions to 2-(Alkylidene)cyclohexanones: Is it higher than that of 2-cyclohexenones?
(Elsevier, 1993-04-23)
2-(Alkylidene)cyclohexanones embedded in steroid systems underwent 1,2-addition of both small and sterically demanding nucleophiles to yield exclusively the axial adducts, supporting the suggestion that 2-(alkylidene)cyc ...
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-01)
New empirical scoring functions have been developed to estimate the binding affinity of a given protein-ligand complex with known three-dimensional structure. These scoring functions include terms accounting for van der ...
Voronoi binding site models
(John Wiley & Sons, Inc., 1987-10)
A frequently occurring problem in drug design and enzymology is that the binding constants for several compounds to the same site are known, but the geometry and energetic interactions of the site are not. This paper ...
Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III: Modeling hydrophobic interactions
(John Wiley & Sons, Inc., 1988-01)
In an earlier article 8 the need was demonstrated for atomic physicochemical properties for three dimensional structure directed quantitative structure-activity relationships, and it was shown how atomic parameters can ...
Improving the intestinal mucosal cell uptake of water insoluble compounds
(Elsevier, 1985-11)
A significant increase in intestinal mucosal cell uptake rate can be achieved by making brush border enzyme-labile derivatives of water insoluble compounds. The test compounds chosen were decanol, hexadecanol, their ...