Now showing items 1-10 of 28
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...
Modulation of [mu]-mediated antinociception by [delta] agonists: characterization with antagonists
(Elsevier, 1989-10-04)
The functional interactions between supraspinal [mu] and [delta] receptors were characterized in the mouse using [mu] receptor-selective antagonists. The effects of pretreatment with the [mu] opioid antagonists, ...
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats
(Elsevier, 1988)
The effects of highly selective mu and delta opioid peptide agonists were determined in two rat models of experimentally-induced convulsions, the flurothyl threshold test and the maximal electroshock test. Intracerebroventricular ...
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective [delta] agonist in vivo
(Elsevier, 1990)
The present study has characterized the antinociceptive actions of [D-Ala2]deltorphin II following intracerebroventricular (i.c.v.) administration in the mouse tail-flick test. [D-Ala2]deltorphin II produced dose- and ...
Complementarity of Δ opioid ligand pharmacophore and receptor models
(John Wiley & Sons, Inc., 1999)
The elaboration of a pharmacophore model for the Δ opioid receptor selective ligand JOM-13 (Tyr–c[ D -Cys–Phe– D -Pen]OH) and the parallel, independent development of a structural model of the Δ receptor are summarized. ...
Opioid [delta] receptor subtypes are associated with different potassium channels
(Elsevier, 1991-01-25)
Discriminative stimulus effects of a centrally administered, delta-opioid peptide ( d -Pen 2 - d -Pen 5 -enkephalin) in pigeons
(Springer-Verlag, 1996-10)
The present study assessed the discriminative stimulus effects of the delta-opioid agonist [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between ICV injections ...
Selective modulation of morphine antinociception, but not development of tolerance, by [delta] receptor agonists
(Elsevier, 1990-09-04)
Co-administration of [delta] opioid agonists at doses which do not produce measurable antinociception were demonstrated to produce an increase in the antinociceptive potency of morphine in the mouse tail-flick test. In ...
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (d-Pen2-d-Pen5-enkephalin) in pigeons
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1996-10)
The present study assessed the discriminative stimulus effects of the delta-opioid agonist [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between ICV injections ...
Thermodynamic parameters for [D-Pen2,5]enkephalin at [delta]-opioid receptors in the mouse isolated vas deferens
(Elsevier, 1993-02-15)
Dissociation constants (KA) for [D-Pen2,5]enkephalin (DPDPE) inhibition of the electrically evoked twitch of the mouse isolated vas deferens preparations (MVD) were calculated at five temperatures (25, 30, 34, 37 and ...