Now showing items 21-28 of 28
Thermodynamic model of secondary structure for α-helical peptides and proteins
(Wiley Subscription Services, Inc., A Wiley Company, 1997-08)
A thermodynamic model describing formation of α-helices by peptides and proteins in the absence of specific tertiary interactions has been developed. The model combines free energy terms defining α-helix stability in aqueous ...
Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligard with high delta opioid receptor selectivity and affinity
(Elsevier, 1988)
Tetrapeptides of primary sequence Tyr-X-Phe-YNH2, where X is D-Cys or D-Pen (penicillamine) and where Y is D-Pen or L-Pen, were prepared and were cyclized via the side chain sulfurs of residues 2 and 4 to disulfide or ...
Synthesis of 6- or 7-substituted 1,2,3,4-tetrahydroisoquinoline- 3-carboxylic acids
(Kluwer Academic Publishers; Springer Science+Business Media, 1999-03)
A straightforward approach for the synthesis of several new, aryl-substituted derivatives of the conformationally constrained phenylalanine analogue 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) is described. Tic, ...
Opioid [delta]-receptor involvement in supraspinal and spinal antinociception in mice
(Elsevier, 1987-09-08)
The possibility that the opioid [delta]-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective [mu]- and [delta]-agonists and -antagonists. Antinociceptive ...
Prediction of protein structure: The problem of fold multiplicity
(John Wiley & Sons, Inc., 1999)
Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible Β-sheet topologies, assembly of amphiphilic ...
Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists
(Elsevier, 1986-11-10)
The apparent affinity of naloxone at cerebral and spinal sites was estimated using selective mu [D-Ala2, Gly-ol5]-enkephalin (DAGO) and delta [D-Pen2, D-Pen5]enkephalin] (DPDPE) opioid agonists in the mouse warm water ...
Pharmacophore elements of the TIPP class of delta opioid receptor antagonists
(Kluwer Academic Publishers; ESCOM Science Publishers B.V. ; Springer Science+Business Media, 1994-10)
A series of tri-and tetrapeptides sharing the amino-terminal dipeptide unit Tyr-Tic, found in the high-affinity delta opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP), was prepared and evaluated in receptor binding assays ...
Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide Tyr-c[ D -Cys-Phe- D -Pen] OH with other conformationally constrained δ-receptor selective ligands
(Wiley Subscription Services, Inc., A Wiley Company, 1996-02)
We have previously proposed a model of the δ-opioid receptor bound conformation for the cyclic tetrapeptide, Tyr-c[ D -Cys-Phe- D -Pen]OH (JOM-13) based on its conformational analysis and from conformation-affinity ...