Now showing items 1-10 of 69
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocol for postoperative pain is to infuse anesthetic solution around nerves or into the epidural space. This clinical practice is beset by the short duration of the anesthetic effect unless the infusion ...
Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-06)
Purpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation ...
Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-07)
Cluster distance geometry of polypeptide chains
(Wiley Subscription Services, Inc., A Wiley Company, 2004-07-30)
Distance geometry has been a broadly useful tool for dealing with conformational calculations. Customarily each atom is represented as a point, constraints on the distances between some atoms are obtained from experimental ...
Biomedical application of immobilized enzymes
(John Wiley & Sons, Inc., 2000-08)
Reports on chemical immobilization of proteins and enzymes first appeared in the 1960s. Since then, immobilized proteins and enzymes have been widely used in the processing of variety of products and increasingly used in ...
Differential Recognition of ACE Inhibitors in Xenopus Laevis Oocytes Expressing Rat PEPT1 and PEPT2
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
Purpose . To examine the mechanism of inhibition of glycylsarcosine(GlySar) transport by quinapril and enalapril, and whether or notangiotensin converting enzyme (ACE) inhibitors are transported by PEPT2as well as by PEPT1.
Effects of magnification and zooming on depth perception in digital stereomammography: an observer performance study
(IOP Publishing Ltd, 2003-11-21)
We are evaluating the application of stereoscopic imaging to digital mammography. In the current study, we investigated the effects of magnification and zooming on depth perception. A modular phantom was designed which ...
Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae
(Springer-Verlag, 2006-02-22)
Tylosin polyketide synthase (Tyl PKS) was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin PKS gene cluster using two compatible low-copy plasmids, each under the ...
CASA: An Efficient Automated Assignment of Protein Mainchain NMR Data Using an Ordered Tree Search Algorithm
(Kluwer Academic Publishers; Springer, 2005-12)
Rapid analysis of protein structure, interaction, and dynamics requires fast and automated assignments of 3D protein backbone triple-resonance NMR spectra. We introduce a new depth-first ordered tree search method of ...
Microscale sample deposition onto hydrophobic target plates for trace level detection of neuropeptides in brain tissue by MALDI-MS
(John Wiley & Sons, Ltd., 2005-10)
A sample preparation method that combines a modified target plate with a nanoscale reversed-phase column (nanocolumn) was developed for detection of neuropeptides by matrix-assisted laser desorption/ionization time-of-flight ...