Now showing items 31-40 of 69
Pre dialysis of blood prime in continuous hemodialysis normalizes pH and electrolytes
(Springer-Verlag; IPNA, 2003-11)
In critically ill children weighing <10 kg, it is necessary to use blood as a priming solution for the extracorporeal continuous renal replacement therapy (CRRT) circuit before initiating CRRT to prevent hemodilution and ...
Floxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolism
(Springer-Verlag; Springer Science + Business Media, Inc., 2005-09)
The aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridine (floxuridine) to enhance intestinal absorption and resistance to glycosidic bond metabolism.
Stabilization and Controlled Release of Bovine Serum Albumin Encapsulated in Poly(D, L-lactide) and Poly(ethylene glycol) Microsphere Blends
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-06)
Purpose . The acidic microclimate in poly(D, L-lactide-co-glycolide) 50/50 microspheres has been previously demonstrated by our group as the primary instability source of encapsulated bovine serum albumin (BSA). The ...
Pharmacophore and receptor models for neurokinin receptors
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-11)
Three neurokinin (NK) antagonist pharmacophore models (Models 1–3) accounting for hydrogen bonding groups in the `head' and `tail' of NK receptor ligands have been developed by use of a new procedure for treatment of ...
Aquifex aeolicus 3-Deoxy- d - manno -2-Octulosonic Acid 8-Phosphate Synthase: A New Class of KDO 8-P Synthase?
(Springer-Verlag; Springer-Verlag New York Inc., 2001-02)
The relationship between 3-deoxy- d - manno 2-octulosonic acid 8-phosphate (KDO 8-P) synthase and 3-deoxy- d - arabino -2-heptulosonic acid 7-phosphate (DAH 7-P) synthase has not been adequately addressed in the literature. ...
Preliminary Investigation into the Expression of Proton-Coupled Oligopeptide Transporters in Neural Retina and Retinal Pigment Epithelium (RPE): Lack of Functional Activity in RPE Plasma Membranes
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-09)
Purpose . To determine the expression and functional activity of proton-coupled oligopeptide transporters (POT) in retinal pigment epithelial (RPE) cells.
Dissolution of ionizable water-insoluble drugs: The combined effect of pH and surfactant
(John Wiley & Sons, Inc., 2000-02)
This study reports the results of the combined effect of pH and surfactant on the dissolution of piroxicam (PX), an ionizable water-insoluble drug in physiological pH. The intrinsic dissolution rate ( J total ) of PX was ...
Stabilization of a model formalinized protein antigen encapsulated in poly(lactide- co -glycolide)-based microspheres
(John Wiley & Sons, Inc., 2001-10)
A formaldehyde-mediated aggregation pathway (FMAP) has been shown to be primarily responsible for the solid-state aggregation of lyophilized formalinized protein antigens [e.g., tetanus toxoid (TT) and formalinized bovine ...
Biowaiver monographs for immediate release solid oral dosage forms: Isoniazid A project of the International Pharmaceutical Federation FIP, Groupe BCS, www.fip.org/bcs .
(Wiley Subscription Services, Inc., A Wiley Company, 2007-03)
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing isoniazid as the only active pharmaceutical ...
Biowaiver monographs for immediate release solid oral dosage forms: Cimetidine This paper reflects the scientific opinion of the authors and not the policies of regulating agencies.
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05)
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the ...