Now showing items 51-60 of 69
Comparison of Human Duodenum and Caco-2 Gene Expression Profiles for 12,000 Gene Sequences Tags and Correlation with Permeability of 26 Drugs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-10)
Purpose . To compare gene expression profiles and drug permeability differences in Caco-2 cell culture and human duodenum.
Estradiol attenuates the K + -induced increase in extracellular GABA in rat striatum
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
Estradiol acts rapidly and directly to inhibit L-type Ca 2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain Γ-aminobutyric acid (GABA), we hypothesized that estradiol inhibition of Ca 2+ ...
Computational studies and peptidomimetic design for the human p53–MDM2 complex
(Wiley Subscription Services, Inc., A Wiley Company, 2005-01-01)
The interaction between human p53 and MDM2 is a key event in controlling cell growth. Many studies have suggested that a p53 mimic would be sufficient to inhibit MDM2 to reduce cell growth in cancerous tissue. In order to ...
Absorption Rate Limit Considerations for Oral Phosphate Prodrugs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-06)
Purpose . To evaluate the potential of phosphate ester prodrugs to significantly improve the absorptive flux of poorly soluble parent drugs.
Glycyl- l -Glutamine Disposition in Rat Choroid Plexus Epithelial Cells in Primary Culture: Role of PEPT2
(Springer-Verlag; Springer Science + Business Media, Inc., 2005-08)
The purpose of this research was to determine the polarity and directionality of the PEPT2-mediated uptake and transepithelial transport of the neuropeptide glycyl- l -glutamine (GlyGln) in choroid plexus.
Capillary liquid chromatography with MS 3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely–moving rats
(John Wiley & Sons, Ltd., 2005-02)
In vivo microdialysis sampling was coupled to capillary liquid chromatography (LC)/electrospray ionization quadrupole ion trap mass spectrometry (MS) to monitor [Met]enkephalin and [Leu]enkephalin in the striatum of ...
A Less Toxic Heparin Antagonist—Low Molecular Weight Protamine
(Kluwer Academic Publishers-Plenum Publishers; MAIK “Nauka/Interperiodica” ; Springer Science+Business Media, 2003-01)
A new thirteen amino acid peptide, named low molecular weight protamine (LMWP), was obtained through the enzymatic digestion of native protamine. Both in vitro and in vivo results showed that LMWP fully maintained the ...
Statistical mechanics of protein folding by cluster distance geometry
(Wiley Subscription Services, Inc., A Wiley Company, 2004-10-15)
This is our second type of model for protein folding where the configurational parameters and the effective potential energy function are chosen in such a way that all conformations are described and the canonical partition ...
Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-05)
Purpose. The purpose of this work was to determine the jejunal permeability of cyclosporin A (CsA) in humans and whether formulation variables modulate the effects of P-glycoprotein (P-gp) on the permeability of CsA in ...
Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits
(John Wiley & Sons, Ltd., 2004-06-15)
Electrospray sample deposition was explored for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). In this method, nanoliter volumes of matrix/analyte mixture were electrosprayed ...