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Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine
(John Wiley & Sons, Ltd., 2004-01)
Purpose —Amifostine is a prodrug in which selectivity is largely determined by the preferential formation and uptake of its cytoprotective metabolite, WR-1065, in normal tissues as a result of differences in membrane-bound ...