Now showing items 1-3 of 3
Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the [delta]non-complexed-opioid receptor
(Elsevier, 1991-01-17)
Substantial evidence has been accumulated which suggests that opioid [delta] receptors may be distinguished on the basis of their involvement in the modulation (i.e., increase or decrease in potency) of [mu]-mediated ...
Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligard with high delta opioid receptor selectivity and affinity
(Elsevier, 1988)
Tetrapeptides of primary sequence Tyr-X-Phe-YNH2, where X is D-Cys or D-Pen (penicillamine) and where Y is D-Pen or L-Pen, were prepared and were cyclized via the side chain sulfurs of residues 2 and 4 to disulfide or ...
Pharmacophore elements of the TIPP class of delta opioid receptor antagonists
(Kluwer Academic Publishers; ESCOM Science Publishers B.V. ; Springer Science+Business Media, 1994-10)
A series of tri-and tetrapeptides sharing the amino-terminal dipeptide unit Tyr-Tic, found in the high-affinity delta opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP), was prepared and evaluated in receptor binding assays ...