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Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
The pharmacokinetics of ibuprofen are complicated by the unidirectional metabolic inversion of the (–)-R- to ( + )-S-enantiomer. Chiral inversion is of therapeutic significance since the drug’s pharmacologic activity has ...
Stereoselective Disposition of Ibuprofen Enantiomers in the Isolated Perfused Rat Kidney
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-12)
The renal clearance of ibuprofen enantiomer was studied separately in the isolated perfused rat kidney at initial perfusate concentrations of 10 µg/ml ( n = 4) and 100 µg/ml ( n = 4). Perfusate and urine samples were ...