Now showing items 1-10 of 83
Development of Acute Tolerance to Bumetanide: Constant-Rate Infusion Studies
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1988-02)
Bumetanide was administered intravenously to four mongrel dogs as a bolus of 8.7 µg/kg, immediately followed by a constant-rate infusion of 0.35 µg/min/kg at 0.036 ml/min. Treatment A consisted of a 90-min equilibration ...
Linearized embedding: A new metric matrix algorithm for calculating molecular conformations subject to geometric constraints
(John Wiley & Sons, Inc., 1989-10)
There are many methods in the literature for calculating conformations of a molecule subject to geometric constraints, such as those derived from two-dimensional NMR experiments. One of the most general ones is the EMBED ...
Carrier mediated transport of amino acids, small peptides, and their drug analogs
(Elsevier, 1987-12)
The oral absorption of amino acids, small peptides and their analogs has been studied in rats using single pass intestinal perfusion. The experimental data was analyzed using a modified boundary layer method permitting the ...
Electrolysis-induced myocardial dysfunction : A novel method for the study of free radical mediated tissue injury
(Elsevier, 1986-07)
Oxygen-derived free radicals and other oxidizing species are thought to be involved in inflammation and ischemic tissue injuries. Recently, oxygen-derived free radicals also have been implicated in tissue injury of the ...
Plasma protein binding of furosemide in kidney transplant patients
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1982-12)
The present investigation was undertaken in order to determine the in vivo plasma protein binding of furosemide in kidney transplant patients and its possible consequence on furosemide effect. Using an equilibrium dialysis ...
A mathematical model to describe drug release from thin topical applications
(Elsevier, 1989-12-01)
Release of a thin topical application of a drug is modeled by transient diffusion between the application, the underlying stratum corneum, and a receptor. Cases treated include sudden contact of the application with drug-free ...
Biotransformation of furosemide in kidney transplant patients
(Springer-Verlag, 1983-11)
The metabolic fate of furosemide was studied in kidney transplant patients after oral and intravenous administration of the diuretic at therapeutic doses. Serial urine samples were collected over a 24 h period and furosemide ...
Inhibition of herpes simplex virus DNA replication by ara-tubercidin
(Elsevier, 1987-09)
Preliminary studies of the biochemical basis for the antiviral activity of the pyrrolo[2,3-d]pyrimidine nucleoside ara-tubercidin were conducted. Herpes simplex virus DNA synthesis was 3-fold more sensitive to inhibition ...
Salicylsalicylic acid causes less gastroduodenal mucosal damage than enteric-coated aspirin
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1989-02)
The gastroduodenal mucosal damage caused by aspirin and nonsteroidal antiinflammatory drugs is a common clinical problem. We compared two medications designed to diminish mucosal damage: enteric-coated aspirin and ...
Electroencephalographic assessment of the role of [delta] receptors in opioid peptide - induced seizures
(Elsevier, 1984-12)
DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for [delta] opioid receptors. Intracerebroventricular (i.c.v.) ...