Now showing items 1-10 of 1505
Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-04)
In this study the intestinal degradation and absorption of a synthetic pentapeptide, metkephamid, were investigated in the rat by determination of its wall permeabilities in the small and large intestine and the extent and ...
Letter to the Editor
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1999-02)
Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
The pharmacokinetics of ibuprofen are complicated by the unidirectional metabolic inversion of the (–)-R- to ( + )-S-enantiomer. Chiral inversion is of therapeutic significance since the drug’s pharmacologic activity has ...
Development of Acute Tolerance to Bumetanide: Constant-Rate Infusion Studies
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1988-02)
Bumetanide was administered intravenously to four mongrel dogs as a bolus of 8.7 µg/kg, immediately followed by a constant-rate infusion of 0.35 µg/min/kg at 0.036 ml/min. Treatment A consisted of a 90-min equilibration ...
Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1990-08)
Polyethylene glycols (PEGs) 600,1000, and 2000 were used to study the molecular weight permeability dependence in the rat nasal and gastrointestinal mucosa. Absorption of the PEGs was measured by following their urinary ...
Plasma protein binding of furosemide in kidney transplant patients
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1982-12)
The present investigation was undertaken in order to determine the in vivo plasma protein binding of furosemide in kidney transplant patients and its possible consequence on furosemide effect. Using an equilibrium dialysis ...
A mathematical model to describe drug release from thin topical applications
(Elsevier, 1989-12-01)
Release of a thin topical application of a drug is modeled by transient diffusion between the application, the underlying stratum corneum, and a receptor. Cases treated include sudden contact of the application with drug-free ...
Pharmacokinetics and pharmacodynamics of pirmenol enantiomers in coronary artery ligated dogs
(John Wiley & Sons, Inc., 1997-04)
The pharmacokinetics and pharmacodynamics of pirmenol enantiomers were investigated in coronary artery ligated mongrel dogs. Reduction in frequency of premature ventricular complexes (PVCs) was determined following intravenous ...
Drug Marker Absorption in Relation to Pellet Size, Gastric Motility and Viscous Meals in Humans
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-02)
Purpose . The objective of this study was to evaluate drug marker absorption in relation to the gastric emptying (GE) of 0.7 mm and 3.6 mm enteric coated pellets as a function of viscosity and the underlying gastric motility.
Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2001-06)
Purpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation ...