Now showing items 1-10 of 330
On the use of structural equation models in experimental designs: Two extensions
(Elsevier, 1991-06)
Bagozzi and Yi (1989) recently introduced new procedures for using structural equation models in experimental designs with . We extend their research by showing that the structural equation analysis of experimental designs ...
Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-04)
In this study the intestinal degradation and absorption of a synthetic pentapeptide, metkephamid, were investigated in the rat by determination of its wall permeabilities in the small and large intestine and the extent and ...
Letter to the Editor
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1999-02)
Cysteine 265 Is in the Active Site of, But Is Not Essential for Catalysis by tRNA-Guanine Transglycosylase (TGT) from Escherichia coli
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1997-01)
Site-directed mutagenesis and X-ray absorption spectroscopy studies have previously shown that the tRNA-guanine transglycosylase (TGT) from Escherichia coli is a zinc metalloprotein and identified the enzymic ligands to ...
Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
The pharmacokinetics of ibuprofen are complicated by the unidirectional metabolic inversion of the (–)-R- to ( + )-S-enantiomer. Chiral inversion is of therapeutic significance since the drug’s pharmacologic activity has ...
Development of Acute Tolerance to Bumetanide: Constant-Rate Infusion Studies
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1988-02)
Bumetanide was administered intravenously to four mongrel dogs as a bolus of 8.7 µg/kg, immediately followed by a constant-rate infusion of 0.35 µg/min/kg at 0.036 ml/min. Treatment A consisted of a 90-min equilibration ...
Linearized embedding: A new metric matrix algorithm for calculating molecular conformations subject to geometric constraints
(John Wiley & Sons, Inc., 1989-10)
There are many methods in the literature for calculating conformations of a molecule subject to geometric constraints, such as those derived from two-dimensional NMR experiments. One of the most general ones is the EMBED ...
Carrier mediated transport of amino acids, small peptides, and their drug analogs
(Elsevier, 1987-12)
The oral absorption of amino acids, small peptides and their analogs has been studied in rats using single pass intestinal perfusion. The experimental data was analyzed using a modified boundary layer method permitting the ...
Electrolysis-induced myocardial dysfunction : A novel method for the study of free radical mediated tissue injury
(Elsevier, 1986-07)
Oxygen-derived free radicals and other oxidizing species are thought to be involved in inflammation and ischemic tissue injuries. Recently, oxygen-derived free radicals also have been implicated in tissue injury of the ...