Now showing items 1-4 of 4
A mathematical model to describe drug release from thin topical applications
(Elsevier, 1989-12-01)
Release of a thin topical application of a drug is modeled by transient diffusion between the application, the underlying stratum corneum, and a receptor. Cases treated include sudden contact of the application with drug-free ...
Drug Transport from Thin Applications of Topical Dosage Forms: Development of Methodology
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1988-06)
There are presently no standards for in vitro research dealing with the release and delivery of drugs from semisolid dosage forms, largely because of inherent experimental difficulties. Among the problems, it has proven ...
Bioavailability assessment of topical delivery systems: in vitro delivery of minoxidil from prototypical semi-solid formulations
(Elsevier, 1989-01-15)
An in vitro technique has been developed for evaluating the delivery performance of topical semi-solid formulations. A thin and uniform layer of formulation was applied in facsimile to actual usage conditions by troweling ...
Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1990-10)
Stainless-steel templates of various thicknesses (75, 200, 800, and 1600 µm) were used to apply propylene glycol/water gels containing methyl or propyl p -aminobenzoates to silicone rubber membranes, and drug delivery was ...