In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes
dc.contributor.author | Guo, Yan | en_US |
dc.contributor.author | Shi, Donglu | en_US |
dc.contributor.author | Cho, Hoonsung | en_US |
dc.contributor.author | Dong, Zhongyun | en_US |
dc.contributor.author | Kulkarni, Amit | en_US |
dc.contributor.author | Pauletti, Giovanni M. | en_US |
dc.contributor.author | Wang, Wei | en_US |
dc.contributor.author | Lian, Jie | en_US |
dc.contributor.author | Liu, Wen | en_US |
dc.contributor.author | Ren, Lei | en_US |
dc.contributor.author | Zhang, Qiqing | en_US |
dc.contributor.author | Liu, Guokui | en_US |
dc.contributor.author | Huth, Christopher | en_US |
dc.contributor.author | Wang, Lumin | en_US |
dc.contributor.author | Ewing, Rodney C. | en_US |
dc.date.accessioned | 2008-10-01T15:24:06Z | |
dc.date.available | 2009-10-02T17:27:37Z | en_US |
dc.date.issued | 2008-09-10 | en_US |
dc.identifier.citation | Guo, Yan; Shi, Donglu; Cho, Hoonsung; Dong, Zhongyun; Kulkarni, Amit; Pauletti, Giovanni M.; Wang, Wei; Lian, Jie; Liu, Wen; Ren, Lei; Zhang, Qiqing; Liu, Guokui; Huth, Christopher; Wang, Lumin; Ewing, Rodney C. (2008). "In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes." Advanced Functional Materials 18(17): 2489-2497. <http://hdl.handle.net/2027.42/60988> | en_US |
dc.identifier.issn | 1616-301X | en_US |
dc.identifier.issn | 1616-3028 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60988 | |
dc.description.abstract | A specially designed carbon nanotube (CNT) is developed for use in the early detection and treatment of cancer. The key functionalities for biomedical diagnosis and drug delivery are incorporated into the CNTs. In vivo imaging of live mice is achieved by intravenously injecting quantum dot (QD)-conjugated CNT for the first time. With near infrared emission around 752 nm, the CNT with surface-conjugated QD (CNT-QD) exhibit a strong luminescence for non-invasive optical in vivo imaging. CNT surface modification is achieved by a plasma polymerization approach that deposited ultra-thin acrylic acid or poly(lactic- co -glycolic acid) (PLGA) films (∼3 nm) onto the nanotubes. The anticancer agent paclitaxel is loaded at 112.5 ± 5.8 µg mg −1 to PLGA-coated CNT. Cytotoxicity of this novel drug delivery system is evaluated in vitro using PC-3MM2 human prostate carcinoma cells and quantified by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The in vivo distribution determined by inductively coupled plasma mass spectrometry (ICP-MS) indicates CNT-QD uptake in various organs of live animals. | en_US |
dc.format.extent | 761375 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | In vivo Imaging and Drug Storage by Quantum-Dot-Conjugated Carbon Nanotubes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Engineering (General) | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Geological Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering University of Michigan Ann Arbor, MI 48109 (USA) | en_US |
dc.contributor.affiliationum | Departments of Geological Sciences, Nuclear Engineering & Radiological Sciences and Materials Science & Engineering University of Michigan Ann Arbor, MI 48109 (USA) | en_US |
dc.contributor.affiliationother | Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.contributor.affiliationother | Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA) ; The Research Institute of Micro/Nano Science & Technology Shanghai Jiao Tong University and College of Materials Science and Engineering, Tongji University Shanghai, 200092 (PR China) ; Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA). | en_US |
dc.contributor.affiliationother | Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, College of Medicine University of Cincinnati Cincinnati, OH 45267 (USA) | en_US |
dc.contributor.affiliationother | James L. Winkle College of Pharmacy University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.contributor.affiliationother | James L. Winkle College of Pharmacy University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.contributor.affiliationother | Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.contributor.affiliationother | Department of Mechanical, Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy, NY 12180 (USA) | en_US |
dc.contributor.affiliationother | Research Center for Biomedical Engineering, Medical College Xiamen University Xiamen, Fujian 361005 (PR China) | en_US |
dc.contributor.affiliationother | Research Center for Biomedical Engineering, Medical College Xiamen University Xiamen, Fujian 361005 (PR China) | en_US |
dc.contributor.affiliationother | Research Center for Biomedical Engineering, Medical College Xiamen University Xiamen, Fujian 361005 (PR China) | en_US |
dc.contributor.affiliationother | Chemistry Division Argonne National Laboratory Argonne, IL 60439 (USA) | en_US |
dc.contributor.affiliationother | Department of Chemical and Materials Engineering, University of Cincinnati Cincinnati, OH 45221 (USA) | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60988/1/2489_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/adfm.200800406 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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