Now showing items 121-130 of 130
Cerium chloride as a histochemical marker of hydrogen peroxide in reperfused ischemic hearts
(Elsevier, 1990-01)
Hydrogen peroxide (H2O2) has been implicated in cardiac damage due to ischemia and reperfusion. We adapted an electron microscopic, histochemical method for demonstrating H2O2 produced by isolated cells to isolated, ...
Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury
(Elsevier, 1988-05)
Ischemic-reperfusion lung injury is a factor potentially limiting the usefulness of distant organ procurement for heart-lung transplantation. Toxic oxygen metabolites are considered a major etiologic factor in reperfusion ...
Attitude and Self-reported Practice Regarding Prognostication in a National Sample of Internists
(Archives of Internal Medicine, 1998-11-23)
Background Since prognostication appears increasingly important in clinical practice, especially in end-of-life care, we examined physicians' experiences and attitudes regarding it.
Methods We mailed a survey to a ...
Clinical characteristics of patients with acute pulmonary embolism
(Elsevier, 1991-12-15)
Among 117 patients with pulmonary embolism (PE) and no prior cardiac or pulmonary disease who participated in the National Heart, Lung, and Blood Institute Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) ...
Trajectories of Recovery and Dysfunction after Acute Illness, with Implications for Clinical Trial Design
(2012-08-15)
We do not understand the trajectories of recovery after critical illness, and this limits our ability to appropriately evaluate novel interventions in randomized controlled trials
Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme
(Springer-Verlag, 2002-04)
Leukotrienes are inflammatory mediators involved in several diseases. The enzyme 5-lipoxygenase initiates the synthesis of leukotrienes from arachidonic acid. Little structural information is available regarding 5-lipoxygenase. ...
Disparate gene expression of chemotactic cytokines by human mononuclear phagocytes
(Elsevier, 1990-01-30)
Chemotactic cytokines are becoming increasingly recognized as important participants in the coordinate recruitment of specific inflammatory cells. In this manuscript we present data demonstrating that LPS challenged human ...
TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
(WILEY-VCH Verlag, 2007-10)
Type 1 (Th1) granulomas can be studied in mice sensitized with mycobacterium antigens followed by challenge of agarose beads covalently coupled to purified protein derivative. TLR9 is known to play a role in the regulation ...
Temperature and time stability of whole blood lactate: implications for feasibility of pre-hospital measurement.
(BMC, 2011-05)
Background
To determine the time and temperature stability of whole blood lactate using experimental conditions applicable to the out-of-hospital environment.
Findings
We performed a prospective, clinical laboratory-based ...