Autophagy fights disease through cellular self-digestion
dc.contributor.author | Mizushima, Noboru | en_US |
dc.contributor.author | Levine, Beth | en_US |
dc.contributor.author | Cuervo, Ana Maria | en_US |
dc.contributor.author | Klionsky, Daniel J. | en_US |
dc.date.accessioned | 2009-06-01T17:36:18Z | |
dc.date.available | 2009-06-01T17:36:18Z | |
dc.date.issued | 2008-02-28 | en_US |
dc.identifier.citation | Mizushima, Noboru; Levine, Beth; Cuervo, Ana Maria; Klionsky, Danial J.. (2008) "Autophagy fights disease through cellular self-digestion." Nature 451(7182): 1069-1075. <http://hdl.handle.net/2027.42/62766> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62766 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18305538&dopt=citation | en_US |
dc.description.abstract | Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health. | en_US |
dc.format.extent | 3874794 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | Autophagy fights disease through cellular self-digestion | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | [Klionsky, Danial J.] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | [Klionsky, Danial J.] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | [Klionsky, Danial J.] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | [Mizushima, Noboru] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan | en_US |
dc.contributor.affiliationother | [Levine, Beth] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA | en_US |
dc.contributor.affiliationother | [Levine, Beth] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA | en_US |
dc.contributor.affiliationother | [Cuervo, Ana Maria] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat, Bronx, NY 10461 USA | en_US |
dc.contributor.affiliationother | [Cuervo, Ana Maria] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Biol Struct, Bronx, NY 10461 USA | en_US |
dc.contributor.affiliationother | [Cuervo, Ana Maria] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Dev & Mol Biol, Bronx, NY 10461 USA | en_US |
dc.identifier.pmid | 18305538 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62766/1/nature06639.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature06639 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | klionsky@umich.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.