A C-elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue
dc.contributor.author | Li, Wei | en_US |
dc.contributor.author | Feng, Z. Y. | en_US |
dc.contributor.author | Sternberg, P. W. | en_US |
dc.contributor.author | Xu, X. Z. Shawn | en_US |
dc.date.accessioned | 2009-06-01T17:36:31Z | |
dc.date.available | 2009-06-01T17:36:31Z | |
dc.date.issued | 2006-03-30 | en_US |
dc.identifier.citation | Li, W; Feng, ZY; Sternberg, PW; Xu, XZS. (2006) "A C-elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue." Nature 440(7084): 684-687. <http://hdl.handle.net/2027.42/62770> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62770 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16572173&dopt=citation | en_US |
dc.description.abstract | The nematode Caenorhabditis elegans is commonly used as a genetic model organism for dissecting integration of the sensory and motor systems(1). Despite extensive genetic and behavioural analyses that have led to the identification of many genes and neural circuits involved in regulating C. elegans locomotion behaviour(1), it remains unclear whether and how somatosensory feedback modulates motor output during locomotion. In particular, no stretch receptors have been identified in C. elegans, raising the issue of whether stretch-receptor-mediated proprioception is used by C. elegans to regulate its locomotion behaviour. Here we have characterized TRP-4, the C. elegans homologue of the mechanosensitive TRPN channel. We show that trp-4 mutant worms bend their body abnormally, exhibiting a body posture distinct from that of wild-type worms during locomotion, suggesting that TRP-4 is involved in stretch-receptor-mediated proprioception. We show that TRP-4 acts in a single neuron, DVA, to mediate its function in proprioception, and that the activity of DVA can be stimulated by body stretch. DVA both positively and negatively modulates locomotion, providing a unique mechanism whereby a single neuron can fine-tune motor activity. Thus, DVA represents a stretch receptor neuron that regulates sensory - motor integration during C. elegans locomotion. | en_US |
dc.format.extent | 378404 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | A C-elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA | en_US |
dc.contributor.affiliationother | CALTECH, Div Biol, Pasadena, CA 91125 USA | en_US |
dc.identifier.pmid | 16572173 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62770/1/nature04538.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature04538 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | shawnxu@umich.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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