Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
dc.contributor.author | Chow, Clement Y. | en_US |
dc.contributor.author | Zhang, Yanling | en_US |
dc.contributor.author | Dowling, James J. | en_US |
dc.contributor.author | Jin, Natsuko | en_US |
dc.contributor.author | Adamska, Maja | en_US |
dc.contributor.author | Shiga, Kensuke | en_US |
dc.contributor.author | Szigeti, Kinga | en_US |
dc.contributor.author | Shy, Michael E. | en_US |
dc.contributor.author | Li, Jun | en_US |
dc.contributor.author | Zhang, Xuebao | en_US |
dc.contributor.author | Lupski, James R. | en_US |
dc.contributor.author | Weisman, Lois S. | en_US |
dc.contributor.author | Meisler, Miriam H. | en_US |
dc.date.accessioned | 2009-06-01T17:40:03Z | |
dc.date.available | 2009-06-01T17:40:03Z | |
dc.date.issued | 2007-07-05 | en_US |
dc.identifier.citation | Chow, Clement Y.; Zhang, Yanling; Dowling, James J.; Jin, Natsuko; Adamska, Maja; Shiga, Kensuke; Szigeti, Kinga; Shy, Michael E.; Li, Jun; Zhang, Xuebao; Lupski, James R.; Weisman, Lois S.; Meisler, Miriam H.. (2007) "Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J." Nature 448(7149): 68-U4. <http://hdl.handle.net/2027.42/62835> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62835 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17572665&dopt=citation | en_US |
dc.description.abstract | Membrane-bound phosphoinositides are signalling molecules that have a key role in vesicle trafficking in eukaryotic cells(1). Proteins that bind specific phosphoinositides mediate interactions between membrane-bounded compartments whose identity is partially encoded by cytoplasmic phospholipid tags. Little is known about the localization and regulation of mammalian phosphatidylinositol-3,5-bisphosphate ( PtdIns( 3,5)P-2), a phospholipid present in small quantities that regulates membrane trafficking in the endosome - lysosome axis in yeast(2). Here we describe a multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation in the 'pale tremor' mouse. Positional cloning identified insertion of ETn2 beta ( early transposon 2 beta)(3) into intron 18 of Fig4 (A530089I17Rik), the homologue of a yeast SAC ( suppressor of actin) domain PtdIns(3,5) P-2 5-phosphatase located in the vacuolar membrane. The abnormal concentration of PtdIns( 3,5) P2 in cultured fibroblasts from pale tremor mice demonstrates the conserved biochemical function of mammalian Fig4. The cytoplasm of fibroblasts from pale tremor mice is filled with large vacuoles that are immunoreactive for LAMP-2 (lysosomal-associated membrane protein 2), consistent with dysfunction of the late endosome - lysosome axis. Neonatal neurodegeneration in sensory and autonomic ganglia is followed by loss of neurons from layers four and five of the cortex, deep cerebellar nuclei and other localized brain regions. The sciatic nerve exhibits reduced numbers of large-diameter myelinated axons, slowed nerve conduction velocity and reduced amplitude of compound muscle action potentials. We identified pathogenic mutations of human FIG4 (KIAA0274) on chromosome 6q21 in four unrelated patients with hereditary motor and sensory neuropathy. This novel form of autosomal recessive Charcot - Marie - Tooth disorder is designated CMT4J. | en_US |
dc.format.extent | 914240 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Dept Cellular & Dev Biol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Texas Childrens Hosp, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA | en_US |
dc.contributor.affiliationother | John D Dingle VA Med Ctr, Detroit, MI 48201 USA | en_US |
dc.identifier.pmid | 17572665 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62835/1/nature05876.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature05876 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | meislerm@umich.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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