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Functional Analysis of MycE and MycF, Two O -Methyltransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibiotics
dc.contributor.authorLi, Shengyingen_US
dc.contributor.authorAnzai, Yojiroen_US
dc.contributor.authorKinoshita, Kenjien_US
dc.contributor.authorKato, Fumioen_US
dc.contributor.authorSherman, David H.en_US
dc.date.accessioned2009-06-01T19:16:46Z
dc.date.available2010-06-02T14:34:28Zen_US
dc.date.issued2009-05-25en_US
dc.identifier.citationLi, Shengying; Anzai, Yojiro; Kinoshita, Kenji; Kato, Fumio; Sherman, David H. (2009). "Functional Analysis of MycE and MycF, Two O -Methyltransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibiotics." ChemBioChem 10(8): 1297-1301. <http://hdl.handle.net/2027.42/62994>en_US
dc.identifier.issn1439-4227en_US
dc.identifier.issn1439-7633en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62994
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19415708&dopt=citationen_US
dc.description.abstractMg motors : We characterized the in vitro function of MycE and MycF, two O -methyltransferases involved in the biosynthesis of mycinamicin antibiotics. Each enzyme was confirmed to be an S -adenosyl- L -methionine (SAM)-dependent deoxysugar methyltransferase. Their optimal activities require the presence of Mg 2+ . With the reconstituted in vitro assays, the order of mycinamicin VI→III→IV in the post-PKS (polyketide synthase) tailoring pathway of mycinamicin was unambiguously determined.en_US
dc.format.extent439830 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWILEY-VCH Verlagen_US
dc.subject.otherChemistryen_US
dc.subject.otherBiochemistry and Biotechnologyen_US
dc.titleFunctional Analysis of MycE and MycF, Two O -Methyltransferases Involved in the Biosynthesis of Mycinamicin Macrolide Antibioticsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLife Sciences Institute, Department of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216 (USA), Fax: (+1) 734-615-3641en_US
dc.contributor.affiliationumLife Sciences Institute, Department of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216 (USA), Fax: (+1) 734-615-3641 ; Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan)en_US
dc.contributor.affiliationumLife Sciences Institute, Department of Medicinal Chemistry, Chemistry, and Microbiology and Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109-2216 (USA), Fax: (+1) 734-615-3641en_US
dc.contributor.affiliationotherSchool of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Kyuban-cho, Koshien, Nishinomiya 663-8179 (Japan)en_US
dc.contributor.affiliationotherFaculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510 (Japan)en_US
dc.identifier.pmid19415708en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62994/1/1297_ftp.pdf
dc.identifier.doi10.1002/cbic.200900088en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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