Replication of genetic associations as pseudoreplication due to shared genealogy
dc.contributor.author | Rosenberg, Noah A. | en_US |
dc.contributor.author | Van Liere, Jenna M. | en_US |
dc.date.accessioned | 2009-09-02T14:39:00Z | |
dc.date.available | 2010-10-05T18:27:29Z | en_US |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Rosenberg, Noah A.; VanLiere, Jenna M. (2009). "Replication of genetic associations as pseudoreplication due to shared genealogy." Genetic Epidemiology 33(6): 479-487. <http://hdl.handle.net/2027.42/63606> | en_US |
dc.identifier.issn | 0741-0395 | en_US |
dc.identifier.issn | 1098-2272 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63606 | |
dc.description.abstract | The genotypes of individuals in replicate genetic association studies have some level of correlation due to shared descent in the complete pedigree of all living humans. As a result of this genealogical sharing, replicate studies that search for genotype-phenotype associations using linkage disequilibrium between marker loci and disease-susceptibility loci can be considered as “pseudoreplicates” rather than true replicates. We examine the size of the pseudoreplication effect in association studies simulated from evolutionary models of the history of a population, evaluating the excess probability that both of a pair of studies detect a disease association compared to the probability expected under the assumption that the two studies are independent. Each of nine combinations of a demographic model and a penetrance model leads to a detectable pseudoreplication effect, suggesting that the degree of support that can be attributed to a replicated genetic association result is less than that which can be attributed to a replicated result in a context of true independence. Genet. Epidemiol. 33:479–487, 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 507532 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Replication of genetic associations as pseudoreplication due to shared genealogy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, Center for Computational Medicine and Biology, and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, Center for Computational Medicine and Biology, and the Life Sciences Institute, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218 | en_US |
dc.contributor.affiliationum | Department of Human Genetics, Center for Computational Medicine and Biology, and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 19191270 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63606/1/20400_ftp.pdf | |
dc.identifier.doi | 10.1002/gepi.20400 | en_US |
dc.identifier.source | Genetic Epidemiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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