The Pattern of Early Lung Parenchymal and Air Space Injury Following Acute Blood Loss
dc.contributor.author | Younger, John G. | en_US |
dc.contributor.author | Taqi, Ali S. | en_US |
dc.contributor.author | Jost, Peter F. | en_US |
dc.contributor.author | Till, Gerd O. | en_US |
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Stern, Susan A. | en_US |
dc.contributor.author | Hirschl, Ronald B. | en_US |
dc.date.accessioned | 2010-06-01T22:12:15Z | |
dc.date.available | 2010-06-01T22:12:15Z | |
dc.date.issued | 1998-07 | en_US |
dc.identifier.citation | Younger, John G.; Taqi, Ali S.; Jost, Peter F.; Till, Gerd O.; Johnson, Kent J.; Stern, Susan A.; Hirschl, Ronald B. (1998). "The Pattern of Early Lung Parenchymal and Air Space Injury Following Acute Blood Loss." Academic Emergency Medicine 5(7): 659-665. <http://hdl.handle.net/2027.42/75222> | en_US |
dc.identifier.issn | 1069-6563 | en_US |
dc.identifier.issn | 1553-2712 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/75222 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9678388&dopt=citation | en_US |
dc.description.abstract | Acute lung injury is a frequent clinical occurrence following blood loss and trauma. The nature of this injury remains poorly understood. Objective : To examine the relative parenchymal and intra-al-veolar distribution of inflammation in a rat model of hemorrhage and resuscitation. Methods : Rats were anesthetized and subjected to hemorrhage followed by resuscitation with shed blood and saline. Myelo-peroxidase activity of lung homogenates and cytology of bronchoalveolar lavage fluid were used to measure total lung and intra-alveolar neutrophil invasion. Extravasation of IV-administered [ 125 I]-albumin was used to determine total lung and alveolar permeability. Permeability results were analyzed using their base-10 logarithmic transformations. Results : 86 animals were studied. Whole-lung myeloperoxidase activity was increased (control = 0.34 ± 0.16 units, injured = 0.84 ± 0.43 units, p < 0.01), while there was no difference in intra-alveolar leukocyte counts (injured = 1.85 ± 1.30 times 10 5 mL, control = 2.44 ± 1.75 times 10 5 mL, p = 0.40), suggesting that the cellular component of the injury was more severe in the intravas-cular and interstitial spaces. There was a strong trend toward increased permeability in the interstitial compartment, and a significant increase in permeability in the intra-alveolar compartment (whole-lung permeability: control =—0.27 ± 0.19 units, injured = 0.10 ± 0.55 units, p = 0.06; alveolar permeability: control = -2.00 ± 0.47 units, injured = -1.32 ± 0.49 units, p < 0.01), suggesting that the loss of integrity to macromolecules was not limited to the interstitium. Conclusion : Hemorrhage and resuscitation resulted in an acute lung injury characterized by extravasation of intravascular protein into both the interstitium and the intra-alveolar space. Neutrophil invasion of the lung was demonstrable only in the interstitial compartment. | en_US |
dc.format.extent | 1072861 bytes | |
dc.format.extent | 3109 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.rights | 1998 Society for Academic Emergency Medicine | en_US |
dc.subject.other | Shock | en_US |
dc.subject.other | Lung | en_US |
dc.subject.other | Trauma-induced ARDS | en_US |
dc.subject.other | Posttraumatic Respiratory Failure | en_US |
dc.title | The Pattern of Early Lung Parenchymal and Air Space Injury Following Acute Blood Loss | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Emergency Medicine Research Laboratories and the Section of Emergency Medicine (JGY, AST, PFJ, SAS), the University of Michigan, Ann Arbor, MI. | en_US |
dc.contributor.affiliationum | the Section of Pediatric Surgery (RBH), the University of Michigan, Ann Arbor, MI. | en_US |
dc.contributor.affiliationum | the Department of Pathology (GOT, KJJ), the University of Michigan, Ann Arbor, MI. | en_US |
dc.identifier.pmid | 9678388 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/75222/1/j.1553-2712.1998.tb02482.x.pdf | |
dc.identifier.doi | 10.1111/j.1553-2712.1998.tb02482.x | en_US |
dc.identifier.source | Academic Emergency Medicine | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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