Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers
Oh, Sam S.; Chang, Shen-Chih; Cai, Lin; Cordon-Cardo, Carlos; Ding, Bao-Guo; Greenland, Sander; He, Na; Jiang, Qingwu; Kheifets, Leeka; Le, Anh; Lee, Yuan-Chin Amy; Liu, Simin; Lu, Ming-Lan; Mao, Jenny T.; Morgenstern, Hal; Mu, Li-Na; Pantuck, Allan; Papp, Jeanette C.; Park, Sungshim Lani; Rao, Jian Yu; Reuter, Victor E.; Tashkin, Donald P.; Wang, Hua; You, Nai-Chieh Y.; Yu, Shun-Zhang; Zhao, Jin-Kou; Belldegrun, Arie; Zhang, Zuo-Feng
2010-11-01
Citation
Oh, Sam S.; Chang, Shen-Chih; Cai, Lin; Cordon-Cardo, Carlos; Ding, Bao-Guo; Greenland, Sander; He, Na; Jiang, Qingwu; Kheifets, Leeka; Le, Anh; Lee, Yuan-Chin Amy; Liu, Simin; Lu, Ming-Lan; Mao, Jenny T.; Morgenstern, Hal; Mu, Li-Na; Pantuck, Allan; Papp, Jeanette C.; Park, Sungshim Lani; Rao, Jian Yu; Reuter, Victor E.; Tashkin, Donald P.; Wang, Hua; You, Nai-Chieh Y.; Yu, Shun-Zhang; Zhao, Jin-Kou; Belldegrun, Arie; Zhang, Zuo-Feng (2010). "Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers." International Journal of Cancer 127(9): 2169-2182. <http://hdl.handle.net/2027.42/78055>
Abstract
Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case-control studies from: Los Angeles (population-based; 611 lung and 553 upper aero-digestive tract cancer cases and 1,040 controls), Taixing, China (population-based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan-Kettering Cancer Center (hospital-based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs . CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50–0.95), and was positively associated with lung cancer among never smokers (TT vs . CT+CC aOR: 2.5, 95% CI: 1.3–5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs . CC aOR: 0.63, 95% CI: 0.41–0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking-related cancer (CC vs . CT+TT aOR: 0.36, 95% CI: 0.17–0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0020-7136 1097-0215
Other DOIs
PMID
20112337
Types
Article
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