Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers
dc.contributor.author | Oh, Sam S. | en_US |
dc.contributor.author | Chang, Shen-Chih | en_US |
dc.contributor.author | Cai, Lin | en_US |
dc.contributor.author | Cordon-Cardo, Carlos | en_US |
dc.contributor.author | Ding, Bao-Guo | en_US |
dc.contributor.author | Greenland, Sander | en_US |
dc.contributor.author | He, Na | en_US |
dc.contributor.author | Jiang, Qingwu | en_US |
dc.contributor.author | Kheifets, Leeka | en_US |
dc.contributor.author | Le, Anh | en_US |
dc.contributor.author | Lee, Yuan-Chin Amy | en_US |
dc.contributor.author | Liu, Simin | en_US |
dc.contributor.author | Lu, Ming-Lan | en_US |
dc.contributor.author | Mao, Jenny T. | en_US |
dc.contributor.author | Morgenstern, Hal | en_US |
dc.contributor.author | Mu, Li-Na | en_US |
dc.contributor.author | Pantuck, Allan | en_US |
dc.contributor.author | Papp, Jeanette C. | en_US |
dc.contributor.author | Park, Sungshim Lani | en_US |
dc.contributor.author | Rao, Jian Yu | en_US |
dc.contributor.author | Reuter, Victor E. | en_US |
dc.contributor.author | Tashkin, Donald P. | en_US |
dc.contributor.author | Wang, Hua | en_US |
dc.contributor.author | You, Nai-Chieh Y. | en_US |
dc.contributor.author | Yu, Shun-Zhang | en_US |
dc.contributor.author | Zhao, Jin-Kou | en_US |
dc.contributor.author | Belldegrun, Arie | en_US |
dc.contributor.author | Zhang, Zuo-Feng | en_US |
dc.date.accessioned | 2010-10-06T14:54:52Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-11-01 | en_US |
dc.identifier.citation | Oh, Sam S.; Chang, Shen-Chih; Cai, Lin; Cordon-Cardo, Carlos; Ding, Bao-Guo; Greenland, Sander; He, Na; Jiang, Qingwu; Kheifets, Leeka; Le, Anh; Lee, Yuan-Chin Amy; Liu, Simin; Lu, Ming-Lan; Mao, Jenny T.; Morgenstern, Hal; Mu, Li-Na; Pantuck, Allan; Papp, Jeanette C.; Park, Sungshim Lani; Rao, Jian Yu; Reuter, Victor E.; Tashkin, Donald P.; Wang, Hua; You, Nai-Chieh Y.; Yu, Shun-Zhang; Zhao, Jin-Kou; Belldegrun, Arie; Zhang, Zuo-Feng (2010). "Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers." International Journal of Cancer 127(9): 2169-2182. <http://hdl.handle.net/2027.42/78055> | en_US |
dc.identifier.issn | 0020-7136 | en_US |
dc.identifier.issn | 1097-0215 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78055 | |
dc.description.abstract | Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco-related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation-related genes with tobacco-related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case-control studies from: Los Angeles (population-based; 611 lung and 553 upper aero-digestive tract cancer cases and 1,040 controls), Taixing, China (population-based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan-Kettering Cancer Center (hospital-based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs . CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50–0.95), and was positively associated with lung cancer among never smokers (TT vs . CT+CC aOR: 2.5, 95% CI: 1.3–5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs . CC aOR: 0.63, 95% CI: 0.41–0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking-related cancer (CC vs . CT+TT aOR: 0.36, 95% CI: 0.17–0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking-related cancers among never smokers. | en_US |
dc.format.extent | 479061 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan, Ann Arbor, MI ; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China | en_US |
dc.contributor.affiliationother | Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY | en_US |
dc.contributor.affiliationother | Taixing City Center for Disease Control and Prevention (CDC), Taixing City, Jiangsu, China | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA ; Department of Statistics, UCLA, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Fudan University School of Public Health, Shanghai, China | en_US |
dc.contributor.affiliationother | Fudan University School of Public Health, Shanghai, China | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | School of Dentistry, University of Southern California, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA ; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA ; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA ; Center for Metabolic Disease Prevention, UCLA, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Departments of Pathology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY | en_US |
dc.contributor.affiliationother | Pulmonary and Critical Care Section, New Mexico VA Healthcare System, Albuquerque, NM | en_US |
dc.contributor.affiliationother | Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY | en_US |
dc.contributor.affiliationother | Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Human Genetics, UCLA, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA ; Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Departments of Pathology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Jiangsu CDC, Nanjing, Jiangsu, China | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Fudan University School of Public Health, Shanghai, China | en_US |
dc.contributor.affiliationother | Gates Foundation Beijing Office, Beijing, China | en_US |
dc.contributor.affiliationother | Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA ; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA ; Tel.: 310-825-8418, Fax: 310-206-6039 ; Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71-225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095-1772, USA | en_US |
dc.identifier.pmid | 20112337 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78055/1/25214_ftp.pdf | |
dc.identifier.doi | 10.1002/ijc.25214 | en_US |
dc.identifier.source | International Journal of Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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