Now showing items 1-10 of 46
STATISTICAL TESTS FOR TAXONOMIC DISTINCTIVENESS FROM OBSERVATIONS OF MONOPHYLY
(Blackwell Publishing Inc, 2007-02)
More TORC for the gluconeogenic engine
(Wiley Subscription Services, Inc., A Wiley Company, 2006-03)
Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the ...
Representation of Somatosensory Evoked Potentials Using Discrete Wavelet Transform
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-04)
Objective. Somatosensory evoked potentials (SEP) have been shown to be a useful tool in monitoring of the central nervous system (CNS) during anaesthesia. SEP analysis is usually performed by an experienced human operator. ...
Algorithms for Selecting Informative Marker Panels for Population Assignment
(Mary Ann Liebert, Inc., publishers, 2005-11-01)
Given a set of potential source populations, genotypes of an individual of unknown origin at a collection of markers can be used to predict the correct source population of the individual. For improved efficiency, informative ...
Efficient tumour formation by single human melanoma cells
(Nature Publishing Group, 2008-12-04)
A fundamental question in cancer biology is whether cells with tumorigenic potential are common or rare within human cancers. Studies on diverse cancers, including melanoma, have indicated that only rare human cancer cells ...
Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway
(WILEY-VCH Verlag, 2007-07)
Synthesis of tetraketide lactones 2 and 3 , which are likely to be produced by a model pikromycin polyketide synthase (PKS), has been investigated. The tetraketide lactones with six-membered rings, 2a and 2b , were ...
Asymmetric and symmetric stem-cell divisions in development and cancer
(Nature Publishing Group, 2006-06-28)
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many ...
Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae
(Springer-Verlag, 2006-02-22)
Tylosin polyketide synthase (Tyl PKS) was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin PKS gene cluster using two compatible low-copy plasmids, each under the ...
Genotype, haplotype and copy-number variation in worldwide human populations
(Nature Publishing Group, 2008-02-21)
Genome-wide patterns of variation across individuals provide a powerful source of data for uncovering the history of migration, range expansion, and adaptation of the human species. However, high-resolution surveys of ...