Now showing items 1-10 of 31
More TORC for the gluconeogenic engine
(Wiley Subscription Services, Inc., A Wiley Company, 2006-03)
Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the ...
Amylin increases cyclic AMP formation in L6 myocytes through calcitonin gene-related peptide receptors
(Elsevier, 1991-06-14)
The cellular function of amylin is investigated in L6 myocytes, a rat skeletal muscle cell line. Both rat amylin and human amylin-amide acutely cause a dose-dependent increase in cyclic AMP formation in L6 myocytes. 100 ...
Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway
(WILEY-VCH Verlag, 2007-07)
Synthesis of tetraketide lactones 2 and 3 , which are likely to be produced by a model pikromycin polyketide synthase (PKS), has been investigated. The tetraketide lactones with six-membered rings, 2a and 2b , were ...
Expression of Mo3e antigen by cultured human umbilical vein endothelial cells (HUVEC) stimulated by phorbol myristate acetate (PMA) and related pharmacological inducers of protein kinase C
(Elsevier, 1988-03)
Mo3e is a protease-sensitive membrane antigen (p75,50) selectively expressed by human monocytic cells (monocytes and U-937 cells) stimulated in vitro by exposure to a variety of activating factors, including phorbol diester ...
Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae
(Springer-Verlag, 2006-02-22)
Tylosin polyketide synthase (Tyl PKS) was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin PKS gene cluster using two compatible low-copy plasmids, each under the ...
Characterization of the Β-Methylaspartate-Α-decarboxylase (CrpG) from the Cryptophycin Biosynthetic Pathway
(WILEY-VCH Verlag, 2007-08-13)
No Abstract
The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen
(Elsevier, 1969-09-10)
The generation of O2-- in the reaction of reduced flavins and several flavoproteins has been shown. This has been demonstrated by the ability to catalyse the aerobic reduction of cytochrome and the inhibition of this ...
Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes
(Elsevier, 1994)
Cobalamin-dependent methionine synthase is a large enzyme composed of structurally and functionally distinct regions. Recent studies have begun to define the roles of several regions of the protein. In particular, the ...
The interaction of nitrous oxide with cobalamin-dependent methionine synthase
(Elsevier, 1991-08)
Rescue of Degradation-Prone Mutants of the FK506-Rapamycin Binding (FRB) Protein with Chemical Ligands
(WILEY-VCH Verlag, 2007-07-09)
We recently reported that certain mutations in the FK506-rapamycin binding (FRB) domain disrupt its stability in vitro and in vivo (Stankunas et al. Mol. Cell , 2003 , 12 , 1615). To determine the precise residues that ...