Now showing items 1-10 of 10
Use of supervised exercise during recovery following sports-related concussion.
(Wolters Kluwer, 2021-03-01)
Objective: To assess the safety of supervised exercise (SE) in acute sport-related concussion (SRC) and its influence on recovery. Design: Retrospective cohort study. Setting: University SRC clinic at a tertiary care center. ...
Interactions Between Motor Thalamic Field Potentials and Single-Unit Spiking Are Correlated With Behavior in Rats
(Frontiers, 2020-08-13)
Field potential (FP) oscillations are believed to coordinate brain activity over large spatiotemporal scales, with specific features (e.g., phase and power) in discrete frequency bands correlated with motor output. ...
A dystonia mouse model with motor and sequencing deficits paralleling human disease.
(Elsevier, 2022-01-24)
The dystonias are a group of movement disorders characterized by involuntary twisting movements and postures. A lack of well characterized behavioral models of dystonia has impeded identification of circuit abnormalities ...
Revisiting the “Paradox of Stereotaxic Surgery”: Insights Into Basal Ganglia-Thalamic Interactions
(Frontiers, 2021-08-27)
Basal ganglia dysfunction is implicated in movement disorders including Parkinson Disease, dystonia, and choreiform disorders. Contradicting standard “rate models” of basal ganglia-thalamic interactions, internal pallidotomy ...
Precisely-Timed Phasic Dopamine Signaling Creates Distinct Kinematic Representations of Skilled Movements
(eLife, 2020-11-27)
Brain dopamine is critical for normal motor control, as evidenced by its importance in Parkinson Disease and related disorders. Current hypotheses are that dopamine influences motor control by 'invigorating' movements and ...
Evolution of gross forelimb and fine digit kinematics during skilled reaching acquisition in rats
(Society for Neuroscience, 2021-09-01)
The ability to learn dexterous motor skills is a fundamental aspect of human behavior. However, the underlying neural circuit mechanisms for dexterous skill learning are unclear. Advancing our understanding of motor skill ...
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
(Elsevier, 2020-07-14)
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from ...
Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-related Epilepsy.
(Wiley, 2023-08-22)
OBJECTIVES: DEPDC5 is a common causative gene in familial focal epilepsy with or without malformations of cortical development. Its pathogenic variants also confer a significantly higher risk for sudden unexpected death ...