Now showing items 1-10 of 652
Cholinergic Receptor-Mediated Phosphorylation and Activation of Tyrosine Hydroxylase in Cultured Bovine Adrenal Chromaffin Cells
(Blackwell Publishing Ltd, 1986-02)
We have identified a 56-kilodalton protein in cultured bovine adrenal chromaffin cells that is phos-phorylated when catecholamine secretion is stimulated. Immunodetection on Western blots from both one- and two-dimensional ...
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
(Springer-Verlag, 1987-02)
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Naltrexone Reduces Ethanol- and/or Water-Reinforced Responding in Rhesus Monkeys: Effect Depends Upon Ethanol Concentration
(Blackwell Publishing Ltd, 1999-09)
The opioid antagonist naltrexone reduces responding for ethanol. If naltrexone produces this effect by blocking ethanol-induced opioid activity, then naltrexone should reduce responding for ethanol regardless of level of ...
Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects,
(Elsevier, 1990-07-01)
In order to evaluate adrenergic function in anxiety disorders, platelet alpha2-adrenergic binding parameters and supine and standing blood pressure, pulse, and venous plasma epinephrine and norepinephrine were determined ...
Chronic haloperidol treatment increased calcium-dependent phosphorylation in rat striatum
(Elsevier, 1982-01-04)
In previous studies, we observed that when rats were chronically treated with haloperidol, there was a significant increase of calmodulin activity in their striatal membranes. Calmodulin is knwon to modulate calcium-dependent ...
Renewed interest in the polyphosphoinositides
(Elsevier, 1984-02)
The significance of the enhanced cellular phosphatidate and phosphatidylinositol turnover which occurs in response to specific extracellular messengers has been the subject of much interest and speculation. Until recently, ...
Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death
(Elsevier, 1983-05)
In anesthetized dogs, a silver wire electrode was inserted into the lumen of the circumflex coronary artery (LCX) and myocardial infarction was produced by a temporary 90-minute occlusion of the left anterior descending ...
The effect of brainstem transection on blood pressure in the dog
(Elsevier, 1969-03-01)
Blood pressure was compared before and after midpontine pretrigeminal brainstem transection in the dog. Statistically significant decreases in blood pressure were observed 1/2, 1, and 1-1/2 hours after brainstem transection. ...