Now showing items 11-20 of 73
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
(Springer-Verlag, 2006-07)
Purpose : This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated ...
Certain 8-amino-9-(benzyl)guanines as potential purine nucleoside phosphorylase inhibitors
(Elsevier, 1994)
Several 8-amino-9-(benzyl)guanines were selected for synthesis as potential purine nucleoside phosphorylase (PNP) inhibitors on the basis of the Topliss decision tree. These compounds were prepared by the treatment of ...
Composition of the aqueous phase of chromaffin granules
(Elsevier, 1979-09-20)
Nuclear magnetic resonance spectroscopy has been used to determine the composition of the aqueous phase of bovine chromaffin granules. Relative concentrations of catecholamines (epinephrine plus norepinephrine), ATP and ...
Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of [beta]-glucosidase inhibition
(Elsevier, 1992-02-01)
Recent work has demonstrated the enhancement of hormone-stimulated inositol trisphosphate formation in renal epithelial cells under conditions of glucosylceramide depletion. The role of glucosylceramide metabolism was ...
Isolation and purification of a squamous cell carcinoma of the head and neck-associated antigen identified by autologous antibody
(Elsevier, 1993-04-30)
We have previously shown that detection of autologous antibody activity to squamous cell carninoma of the head and neck many be augmented by dissociation in immune complexes. Western blot analysis with autologous antibody ...
Determination of plasma trimetrexate levels using gas chromatography--mass spectrometry with selected-ion monitoring
(Elsevier, 1986)
Trimetrexate is a potent inhibitor of dihydrofolate reductase and has demonstrated significant antitumor activity against murine and human cell lines both in vitro and against several murine transplanted tumors. The ...
Changes occur in central adrenoreceptor function following long-term morphine treatment and during morphine withdrawal
(Elsevier, 1984-12)
Radioloigand binding techniques were used in combination with electrophysiological recording to characterize changes in beta adrenoreceptor activity in various brain areas in rats treated chronically with morphine. Following ...
A comparison of cholesteryl oleate and 19-iodocholesteryl oleate as substrates for adrenal cholesterol esterase
(Elsevier, 1980-04)
Radiolabeled 19-iodocholesterol is widely used to obtain images of human adrenals. We have shown in rats and mice that 85-95% of the radiolabel is present in the esterified form. Using rat adrenal cytosolic cholesterol ...
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens
(Elsevier, 1984-12)
The selectivity and relative potencics of opiate receptor antagonists were compared on the mouse vas deferens preparation. ICI-174864 was found to be a highly selective antagonist at delta opiate receptors equal in potency ...
Ion-pair chromatography of inositol polyphosphates with N-methylimipramine
(Elsevier, 1990)
A novel counter-ion, N-methylimipramine, was synthesized and utilized in the separation of inositol phosphates by ion-pair chromatography. The structural identity of the counter-ion was documented by nuclear magnetic ...