Now showing items 21-30 of 206
Some thoughts on the relations between animal and human drug-taking
(Elsevier, 1983)
1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion ...
Changes in cortical [beta]-adrenergic receptor density and neuronal sensitivity to norepinephrine accompany morphine dependence and withdrawal
(Elsevier, 1987-01-01)
Radioligand binding experiments were carried out in conjunction with electrophysiological recordings in vivo in the parietal cortex in rats to assess changes in postsynaptic [beta]-adrenergic receptor function that result ...
Effects of morphine, nalorphine and naloxone on neocortical release of acetylcholine in the rat
(Springer-Verlag, 1973-06)
The effects of morphine (10 mg/kg), nalorphine (1 and 10 mg/kg), and naloxone (1 mg/kg) were studied on the neocortical release of acetylcholine (ACh) in midpontine pretrigeminal transected rats. Morphine and, to a lesser ...
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats
(Springer-Verlag, 1987-09)
Directly observable behavioral effects of the N-methyl- D -aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (AP5) (10–1,000 mg/kg IP, 0.18–5.6 μmol/rat ICV) and of phencyclidine (PCP) (3.2–56 mg/kg IP, ...
Effects of stress and REM sleep deprivation on the patterns of avoidance learning and brain acetylcholine in the mouse
(Springer-Verlag, 1973-12)
Pure bred DBA/2J mice were subjected to varying degrees of stress and “water tank” REM sleep deprivation using one-animal cages, large platforms and/or poles. Subsequently, the animals were studied for acquisition, short-term ...
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons
(Springer-Verlag, 1985-03)
Six pigeons, trained to peck a response key on a fixed-ratio 20 schedule of food reinforcement, were used to examine the effects of morphine, naltrexone, and dextrorphan, before, during, and after chronic treatment with ...
Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate
(Elsevier, 1986-03)
This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing ...
Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line,
(Elsevier, 1990-05)
UM-EC-2 was established from a patient with poorly differentiated stage IB endometrial carcinoma. This cell line produces tumors in nude mice that have the same histological features as the patient's tumor. UM-EC-2 cells ...
Fenfluramine and N-ethyl amphetamine: Comparison of the reinforcing and rate-decreasing actions in the rhesus monkey
(Springer-Verlag, 1975-01)
N-ethyl amphetamine HCl (NEA) and fenfluramine HCl ( meta -trifluoromethyl N-ethyl amphetamine) were evaluated as reinforcers in rhesus monkeys that had been previously trained to press a lever using food presentations and ...
Competitive and uncompetitive N -methyl- d -aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine
(Springer-Verlag, 1995-03)
The purpose of the present studies was to examine representative uncompetitive and competitive NMDA antagonists, as well as the glycine/NMDA antagonist, HA 966, in pigeons trained to discriminate either PCP or CGS 19755 ...