Now showing items 1-10 of 16
Synthesis and regional mouse brain distribution of [11C]Nisoxetine, a norepinephrine uptake inhibitor
(Elsevier, 1989)
Nisoxetine, a selective and high affinity (IC50 = 1 nM) inhibitor of NE reuptake, has been radiolabeled in high specific activity (> 600 Ci/mmol) by the alkylation of the nor-methyl precursor with [11C]CH3I. Synthetic ...
Feasibility of sharpening limited-angle tomography by including an orthogonal set of projections
(Elsevier, 1982-02-15)
In single photon emission nuclear medicine, computed tomography systems that employ only a limited angular range of projection data suffer from blurring in the depth (or z) direction. With simulated data, we show that ...
Radioiodination via isotope exchange in pivalic acid
(Elsevier, 1986)
A variety of benzoic and aryl aliphatic mono and polyiodinated acids and esters (sterol, triglyceride) were radioiodinated in 55-99% radiochemical yield by isotope exchange with Na 125I in a melt of pivalic acid. In general, ...
Metabolic fate of the heart agent [18F]6-fluorometaraminol
(Elsevier, 1989)
Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig ...
Use of DES-treated rats as an animal model for assessment of pituitary adenoma imaging agents
(Elsevier, 1986)
Prolactin (PRL) secreting pituitary adenomas are the most common type of pituitary tumors. An imaging agent which specifically localized in prolactinomas would be of considerable clinical value for both initial detection ...
Potential tumor or organ imaging agents--31. Radioiodinated sterol benzoates and carbamates
(Elsevier, 1989)
A series of radioiodinated benzoate and carbamate esters of cholesterol and pregnenolone wherein the acyl moiety served as the carrier for radioiodine was synthesized and evaluated as potential imaging agents for the adrenal ...
Application of coded apertures in tomographic head scanning
(Elsevier, 1984-03-15)
A circular ring tomograph, designated SPRINT, is under development for single photon emission tomography of the human head. Most data to date have been gathered using a single rotating slit inside the detector ring to ...
[omega]-iodophenyl fatty acids: A convenient method of radioiodination
(Elsevier, 1986)
A solid-phase radioiodination technique for [omega]-iodophenyl fatty acids using ammonium sulfate is described. The radioiodinations are (1) regioselective, (2) high in yield (95%), (3) short in reaction time (1 h) and (4) ...
Multiphase extraction: Rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions
(Elsevier, 1988)
In multiphase extraction [18F]fluoride ion for radiolabeling is recovered from target water by passage through a small column of microporous polymer impregnated with a lipophilic cryptand or quaternary ammonium salt. The ...
NMDA receptor channels: Labeling of MK-801 with iodine-125 and fluorine-18
(Elsevier, 1988)
Methods for labeling the glutamate channel blocking agent MK-801 with iodine-125 (125I) and fluorine-18 (18F) are described. Radioiodine was incorporated in the 1- or 3-positions of the aromatic ring of (+/-)MK-801 by ...