Now showing items 11-16 of 16
Biodistribution, dosimetry, metabolism and monkey PET studies of [18F]GBR 13119. Imaging the dopamine uptake system in vivo
(Elsevier, 1989)
The in vivo charactersitics of a new radiotracer, [18F]GBR 13119, have been examined. Full body biodistribution in rats has been determined and the expected human dosimetry calculated. Pharmacological specificity of in ...
Thiophenes as phenyl bio-isosteres: Application in radiopharmaceutical design--I. Dopamine uptake antagonists
(Elsevier, 1989)
Possible applications of thiophenes in radiopharmaceutical chemistry have been explored. Thiophene for benzene ring substitution was applied to the synthesis of thienyl-[18F]GBR 13119, an analog of the potent and selective ...
Pituitary localization of 3H-spiroperidol by an Uptake/Storage Mechanism?
(Elsevier, 1986)
The lack of a pituitary imaging agent combined with the considerable clinical value for such an agent prompted an examination of 3H-spiroperidol (3HSp). Spiroperidol was selected for initial evaluation based on its high ...
Improving emission-computed-tomography quantification by Compton-scatter rejection through offset windows
(Elsevier, 1986-01-15)
Historically in nuclear medicine the acceptance window for total-energy pulse-height has been set to maximize contrast and resolution in the image. Recently, there has been increased emphasis on quantification of digital ...
A captive solvent method for rapid N-[11C]methylation of secondary amides: Application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)
(Elsevier, 1988)
[11C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepam, in a small volume of acetone adsorbed on acrylic yarn, with [11C]methyl ...
Synthesis of a high specific activity 125I-labeled analog of PK 11195, potential agent for SPECT imaging of the peripheral benzodiazepine binding site
(Elsevier, 1989)
The peripheral benzodiazepine binding site ligand PK 11195 has been 125I-labeled by direct displacement of aromatic chlorine under solid-state conditions in 50-76% radiochemical yield and >94% radiochemical purity. ...