Now showing items 11-20 of 21
Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05-01)
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein-1 (MCP-1, CCL2) has been identified ...
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-01)
Patients with advanced prostate cancer often exhibit increased activation of the coagulation system. The key activator of the coagulation cascade is the serine protease thrombin which is capable of eliciting numerous ...
Concordant copy number and transcriptional activity of genes mapping to derivative chromosomes 8 during cellular immortalization in vitro
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
Deletion, rearrangement, or amplification of sequences mapping to chromosome 8 are frequently observed in human prostate and other tumors. However, it is not clear whether these events alter the transcriptional activity ...
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
(Springer-Verlag, 2006-02)
Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility ...
A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
The pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous “hurdle” to overcome in designing novel cancer ...
Evidence for lectin signaling to the nuclear matrix: Cellular interpretation of the glycocode
(John Wiley & Sons, Inc., 2000)
No abstract
Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2008-10-01)
One of the most life-threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. Our work in this field has ...
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein
(Wiley Subscription Services, Inc., A Wiley Company, 2005-02-01)
Raf kinase inhibitor protein (RKIP) was originally identified as a protein that bound membrane phospholipids and was named phosphatidylethanolamine binding protein-2 (PEBP-2). RKIP was than identified as a protein that ...
CCR2 expression correlates with prostate cancer progression
(Wiley Subscription Services, Inc., A Wiley Company, 2007-06-01)
Although the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development. There is emerging evidence ...
Dynamic process of prostate cancer metastasis to bone
(Wiley Subscription Services, Inc., A Wiley Company, 2004-03-01)
Prostate cancer metastasis to the bone occurs at high frequency in patients with advanced disease, causing significant morbidity and mortality. Over a century ago, the “seed and soil” theory was proposed to explain ...