Now showing items 11-20 of 38
Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
(Wiley Subscription Services, Inc., A Wiley Company, 2004-03-01)
Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on ...
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-01)
Nearly 85% of the men who will die of prostate cancer (PCa) have skeletal metastases present. The ability of PCa cells to interact with the microenvironment determines the success of the tumor cell to form metastatic ...
Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts
(Wiley Subscription Services, Inc., A Wiley Company, 2009-03-01)
Bone is the preferred site of prostate cancer metastasis, contributing to the morbidity and mortality of this disease. A key step in the successful establishment of prostate cancer bone metastases is activation of osteoclasts ...
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression
(Wiley Subscription Services, Inc., A Wiley Company, 2009-04-15)
The metalloproteinase ADAM15 is a multi-domain disintegrin protease that is upregulated in a variety of human cancers. ADAM15 mRNA and protein levels are increased in prostate cancer and its expression is significantly ...
Immunologic Detection of the Cellular Receptor for Urokinase Plasminogen Activator
(Elsevier, 1994-04)
The cellular receptor for urokinase plasminogen activator (uPA-R) is a monomeric phosphatidylinositol-linked glycoprotein (gp40-65) that may contribute to the invasive capacity of tumor and inflammatory cells by focusing ...
Bayesian inference for the stereotype regression model: Application to a case–control study of prostate cancer
(John Wiley & Sons, Ltd., 2009-11-10)
The stereotype regression model for categorical outcomes, proposed by Anderson ( J. Roy. Statist. Soc. B. 1984; 46 :1–30) is nested between the baseline-category logits and adjacent category logits model with proportional ...
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
PAR1-mediated NFΚB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
We have previously reported that protease-activated receptor 1 (PAR1 or thrombin receptor) is over-expressed in metastatic prostate cancer cell lines compared to prostate epithelial cells. In this study, we examined 1,074 ...
Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05-01)
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein-1 (MCP-1, CCL2) has been identified ...
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-01)
Patients with advanced prostate cancer often exhibit increased activation of the coagulation system. The key activator of the coagulation cascade is the serine protease thrombin which is capable of eliciting numerous ...