Gender influences health-related Quality of Life in IPF
Han, MeiLan K.; Swigris, Jeffrey; Liu, Lyrica X.; Bartholmai, Brian; Murray, Susan; Giardino, Nicholas; Thompson, Bruce; Frederick, Margaret; Li, Daner; Schwarz, Marvin; Limper, Andrew; Flaherty, Kevin; Martinez, Fernando J.
2010-05
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2010 Respiratory Medicine - Gender Influences health-related Quality of Life in IPF.pdf
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Respiratory Medicine 2010. vol. 104 no. 5, pp. 724-730. <http://hdl.handle.net/2027.42/91956>
Abstract
Background HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist. Methods Data were drawn from the NIH-sponsored Lung Tissue Research Consortium (LTRC). Demographic and pulmonary physiology data along with MMRC, SF-12, and SGRQ scores from women vs. men were compared with two-sample t-tests. Multivariate linear regression was used to examine the association between SF-12 component scores and gender while adjusting for other relevant variables. Results The study sample consisted of 147 men and 74 women. Among several baseline variables, only DLCO% predicted differed between women and men, (43.7 vs. 38.0, p = 0.03). In general, men exhibited lower (better) MMRC scores (1.7 vs. 2.4, p = 0.02), particularly those with milder disease as measured by DLCO% predicted. In an adjusted analysis, SF-12 PCS scores in men were lower (worse) than women (p = 0.01), an effect that was more pronounced in men with greater dyspnea scores. In a similar analysis, SF-12 MCS scores in women were lower than men (worse) (48.3 vs. 54.4, p = 0.0004), an effect that was more pronounced in women with greater dyspnea scores. Conclusions Significant gender differences in HRQL exist in IPF. As compared to women, men reported less severe dyspnea, had worse SF-12 PCS scores, but better SF-12 MCS scores. Dyspnea appears to have a greater impact on the physical HRQL of men and the emotional HRQL of women. An improved understanding of the mechanism behind these differences is needed to better target interventions.Publisher
Elsevier
Subjects
Interstitial Pulmonary Fibrosis Health-related Quality of Life Gender
Description
Disclosure statements
Dr. Han has received research support from the NIH.
Dr. Bartholmai has received research support from the NIH
and GlaxoSmithKline. Dr. Murray has received research
support from the NIH. Dr. Giardino has received research
support from the VAHS. Dr. Flaherty has received research
support from Intermune and the NIH, consulting honorarium
from GlaxoSmithKline and is a member of advisory boards
for Boehringer Ingelheim and Gilead. Dr. Thompson has
received research support from the NIH. Dr. Frederick has
received research support from the NIH. Ms. Li has received
research support from the NIH. Dr. Schwarz has received
research support from the NIH. Dr. Limper received
consulting fees and a research grant from Novartis and has
received research support from the NIH. Dr. Martinez is
a member of a steering committee for Actelion, Gilead,
Centocor, and Genzyme and has received research support
from Actelion and the NIH.
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Article
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