Gender influences health-related Quality of Life in IPF
dc.contributor.author | Han, MeiLan K. | |
dc.contributor.author | Swigris, Jeffrey | |
dc.contributor.author | Liu, Lyrica X. | |
dc.contributor.author | Bartholmai, Brian | |
dc.contributor.author | Murray, Susan | |
dc.contributor.author | Giardino, Nicholas | |
dc.contributor.author | Thompson, Bruce | |
dc.contributor.author | Frederick, Margaret | |
dc.contributor.author | Li, Daner | |
dc.contributor.author | Schwarz, Marvin | |
dc.contributor.author | Limper, Andrew | |
dc.contributor.author | Flaherty, Kevin | |
dc.contributor.author | Martinez, Fernando J. | |
dc.date.accessioned | 2012-07-03T09:26:24Z | |
dc.date.available | 2012-07-03T09:26:24Z | |
dc.date.issued | 2010-05 | |
dc.identifier.citation | Respiratory Medicine 2010. vol. 104 no. 5, pp. 724-730. <http://hdl.handle.net/2027.42/91956> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/91956 | |
dc.description | Disclosure statements Dr. Han has received research support from the NIH. Dr. Bartholmai has received research support from the NIH and GlaxoSmithKline. Dr. Murray has received research support from the NIH. Dr. Giardino has received research support from the VAHS. Dr. Flaherty has received research support from Intermune and the NIH, consulting honorarium from GlaxoSmithKline and is a member of advisory boards for Boehringer Ingelheim and Gilead. Dr. Thompson has received research support from the NIH. Dr. Frederick has received research support from the NIH. Ms. Li has received research support from the NIH. Dr. Schwarz has received research support from the NIH. Dr. Limper received consulting fees and a research grant from Novartis and has received research support from the NIH. Dr. Martinez is a member of a steering committee for Actelion, Gilead, Centocor, and Genzyme and has received research support from Actelion and the NIH. | en_US |
dc.description.abstract | Background HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist. Methods Data were drawn from the NIH-sponsored Lung Tissue Research Consortium (LTRC). Demographic and pulmonary physiology data along with MMRC, SF-12, and SGRQ scores from women vs. men were compared with two-sample t-tests. Multivariate linear regression was used to examine the association between SF-12 component scores and gender while adjusting for other relevant variables. Results The study sample consisted of 147 men and 74 women. Among several baseline variables, only DLCO% predicted differed between women and men, (43.7 vs. 38.0, p = 0.03). In general, men exhibited lower (better) MMRC scores (1.7 vs. 2.4, p = 0.02), particularly those with milder disease as measured by DLCO% predicted. In an adjusted analysis, SF-12 PCS scores in men were lower (worse) than women (p = 0.01), an effect that was more pronounced in men with greater dyspnea scores. In a similar analysis, SF-12 MCS scores in women were lower than men (worse) (48.3 vs. 54.4, p = 0.0004), an effect that was more pronounced in women with greater dyspnea scores. Conclusions Significant gender differences in HRQL exist in IPF. As compared to women, men reported less severe dyspnea, had worse SF-12 PCS scores, but better SF-12 MCS scores. Dyspnea appears to have a greater impact on the physical HRQL of men and the emotional HRQL of women. An improved understanding of the mechanism behind these differences is needed to better target interventions. | en_US |
dc.description.sponsorship | This work is supported by the Lung Tissue Research Consortium (N01 HR46158 (Bartholmai), N01 HR46160 (Schwarz), N01 HR46161 (Limper), N01 HR46162 (Han, Martinez), N01 HR46164 (Li, Frederick, Thompson), KL2 RR024987 (Han), K24 HL04212 (Martinez). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Interstitial Pulmonary Fibrosis | en_US |
dc.subject | Health-related Quality of Life | en_US |
dc.subject | Gender | en_US |
dc.title | Gender influences health-related Quality of Life in IPF | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Biostatistics | en_US |
dc.contributor.affiliationother | Mayo Clinic, Clinical Trials and Surveys Corporation, University of Colorado, National Jewish Health | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/91956/1/2010 Respiratory Medicine - Gender Influences health-related Quality of Life in IPF.pdf | |
dc.identifier.source | Respiratory Medicine | en_US |
dc.owningcollname | Public Health, School of (SPH) |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.