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Filtering by: Creator Hong, Hanna S. Creator Lyssiotis, Costas A. Creator O'Riordan, Mary X. Creator Zhang, Li Keyword lipopolysaccharide Discipline Health Sciences

Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

Creator:

Reynolds, Mack B., Hong, Hanna S., Zhang, Li, Lyssiotis, Costas A., and O'Riordan, Mary X.

Description:

Untargeted lipidomics (Data S1) and targeted metabolomics (Data S2) analysis from in vitro culture of a murine macrophage cell line expressing shRNA targeted to Cardiolipin synthase (CRLS1), referred to as CRLS1 knockdown (KD), or a paired non-target shRNA-expressing (NT-Control). CRLS1 KD and NT-Control macrophages were either directly analyzed (untargeted lipidomics) or stimulated with lipopolysaccharide for a variety of timepoints and then analyzed (targeted metabolomics). Datasets are available as .csv files.

Keyword:

Lipidomics, Metabolomics, Cardiolipin, Macrophage, CRLS1, lipopolysaccharide, and LPS

Citation to related publication:

Reynolds M.B. et al. (2023). Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Science Advances, 9(5). DOI: 10.1126/sciadv.ade8701

Discipline:

Health Sciences

Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

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Untargeted lipidomics and targeted metabolomics analysis of Cardiolipin synthase deficient murine macrophages

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