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- Creator:
- Carson, William F., IV
- Description:
- Transcriptional accessibility of chromatin is central to guiding CD4+ T cell function through regulation of lineage specific gene expression. Myst1 is a histone acetyltransferase responsible for acetylation of the protein tail of histone 4 at lysine residue 16 (H416ac), resulting in increased transcriptional accessibility and activation of gene transcription. Previous studies have described a role for Myst1 in governing lymphocyte development in the thymus, however the role of Myst1 and H4K16ac in guiding activation of peripheral CD4+ T cells has not been studied. Activation of human and murine CD4+ T cells resulted in upregulation of Myst1 expression, and deletion of Myst1 resulted in changes in proliferative responses to both polyclonal stimulus and exogenous cytokines. Myst1-deficient T cells also exhibited modulations in lineage commitment, with decreased function in TH1/TH2 skewing conditions and increased function in response to TH17-promoting conditions. Regulation of Myst1 function in CD4+ T cells appears governed at least in part by STAT5, as Myst1 expression is regulated by STAT5 expression and DNA binding, and modulations in H4K16ac in Myst1-deficient CD4+ T cells is observable at sites in the promoter regions of lineage specific genes following skewing to the TH1 or TH2 lineage in vitro. Taken together, these results indicate an important role for the STAT5-Myst1 epigenetic axis in governing the activation and effector function of CD4+ T cells.
- Citation to related publication:
- Discipline:
- Science
- Title:
- Data files for manuscript: "Regulation of STAT5-directed CD4+ T cell lineage commitment by the histone acetyltransferase Myst1"
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- Creator:
- Gharzai, Laila A, Green, Michael D, Griffith, Kent A, and Jolly, Shruti
- Description:
- Three sensitivity analyses were performed. First, a second matching step was performed in which two controls were selected for each case, where possible using a nearest neighbor and caliper metric. Controls needed to have propensity scores within 0.1 of the case to be selected. Thirty-eight of the 39 cases had at least one control using this method and for 36 cases two controls could be selected. The average difference between case and control propensity adjuvant RT was 0.008 (range 0.00003-0.095). A second sensitivity analysis was performed to guard against immortal time bias. In order to mitigate the possibility of this effect, cases known not to have undergone adjuvant RT have been screened for suitable follow-up without a recurrence (local or regional recurrence, metastatic failure, and/or death) to ensure that if adjuvant RT had been prescribed as part of the multi-modality treatment regimen, that it would have been initiated. Three months was selected as the mandatory follow-up time. One to one matching was carried out and all 39 cases were matched to a control. A third sensitivity analysis was performed to account for stage migration seen in control patients that presented to the University of Michigan with more advanced disease. Patients that underwent adjuvant radiation were matched one to one with control group patients who did not receive adjuvant radiation, and who had the same stage at diagnosis as compared to stage at University of Michigan presentation.
- Keyword:
- adenocortical carcinoma and English
- Citation to related publication:
- Discipline:
- Health Sciences
- Title:
- Data from: Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma
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- Creator:
- Moser, Carol, Schoenebeck, Sarita Y., and Resnick, Paul
- Description:
- This work investigates what features e-commerce sites use to encourage impulse buying and what tools consumers desire to curb their online spending. We present supplementary material for two studies: (1) a systematic content analysis of 200 top e-commerce websites in the U.S. and (2) a survey of online impulse buyers (N=151). Files include: (1) Study 1 Code book for content analysis of websites (2) Study 1 CSV data file resulting from the content analysis (3) Study 1 PDFs (N=200) of e-commerce websites analyzed (4) Study 2 Online survey questionnaire (5) Study 2 Survey code book for free response questions
- Citation to related publication:
- Discipline:
- Social Sciences
- Title:
- Impulse Buying Content Analysis and Online Survey
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- Creator:
- Zhu, Jialei, Penner, Joyce E., Yu, Fangqun, Sillman, Sanford, Andreae, Meinrat O., and Coe, Hugh
- Description:
- The dataset contains the Fortran programs applied in the latest CESM/IMPACT model as well as the data created from this model, which are used in the referenced paper.
- Keyword:
- Organic nucleation and Radiative forcing
- Citation to related publication:
- Zhu, J. et al. Decrease in radiative forcing by organic aerosol nucleation, climate, and land use change. Nature Communications 10, 423 (24 January 2019).
- Discipline:
- Science
- Title:
- Decrease in radiative forcing by organic aerosol nucleation, climate, and land use change
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- Creator:
- Thomaz, Andréa T. (UMICH), Carvalho, Tiago P. (UFRGS), Malabarba, Luiz R. (UFRGS), and Knowles, L. Lacey (UMICH)
- Description:
- Estimated phylogenetic relationships based on more than 18,000 loci in 93 individuals (full data) or 21 individuals (subset data) representing 19 described species and two putative undescribed species. Nine files are part of this dataset, including all input files to infer the phylogenetic reconstructions and the outputs obtained, in addition to a pruned tree used to infer the ancestral state reconstructions.
- Keyword:
- dusky millions poeciliids, sexual selection, South America, and ddRADseq
- Citation to related publication:
- Andréa T. Thomaz, Tiago P. Carvalho, Luiz R. Malabarba, L. Lacey Knowles, Geographic distributions, phenotypes, and phylogenetic relationships of Phalloceros (Cyprinodontiformes: Poeciliidae): insights about diversification among sympatric species pools, Molecular Phylogenetics and Evolution, 2018, ISSN 1055-7903, https://doi.org/10.1016/j.ympev.2018.12.008
- Discipline:
- Science
- Title:
- Geographic distributions, phenotypes, and phylogenetic relationships of Phalloceros (Cyprinodontiformes: Poeciliidae): insights about diversification among sympatric species pools [DATA SET]
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- Creator:
- Mitchell, Michael
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication https://doi.org/10.3998/mpub.10079890, and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
- Title:
- Student Writing Eportfolio: "Jonah's" Gateway
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- Creator:
- Danko, Melissa
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway, sitesucker , website, and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
- Title:
- Student Writing Eportfolio: "Jenna's" Gateway
-
- Creator:
- Danko, Melissa
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
- Title:
- Student Writing Eportfolio: "Jenna's" Capstone
-
- Creator:
- Schuler, Kaitlin
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
- Title:
- Student Writing Eportfolio: "Amanda's" Gateway
-
- Creator:
- Cockrum, Kayla
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
- Title:
- Student Writing Eportfolio: "Julia's" Capstone