Work Description

Title: Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients [Literature Search Files] Open Access Deposited

http://creativecommons.org/licenses/by/4.0/
Attribute Value
Methodology
  • The data in this work originate from the literature searches of several citation databases, including MEDLINE (Ovid), Embase (Elsevier), Cochrane Central Register of Controlled Trials (Wiley), and Web of Science (Clarivate).
Description
  • The dataset includes most citations considered for inclusion in the scoping review. The citations are accessible in the Endnote file, as well as the primary citation export files from each database. The literature search strategies are included for reproducibility and transparency purposes.
Creator
Depositor
  • markmac@umich.edu
Contact information
Discipline
Keyword
Citations to related material
  • Tan MH, Iyengar R, Mizokami-Stout K, et al. Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports. Clin Diabetes Endocrinol. 2019;5:1. Published 2019 Jan 22. https://doi.org/10.1186/s40842-018-0073-4
Resource type
Last modified
  • 04/27/2020
Published
  • 10/25/2019
Language
DOI
  • https://doi.org/10.7302/7ewc-n350
License
To Cite this Work:
Tan, M., Iyengar, R., Mizokami-Stout, K., Yentz, S., MacEachern, M., Shen, L., Redman, B., Gianchandani, R. (2019). Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients [Literature Search Files] [Data set]. University of Michigan - Deep Blue. https://doi.org/10.7302/7ewc-n350

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Files (Count: 14; Size: 10.1 MB)

30 Records downloaded - Fri Feb 23 19:53:52 UTC 2018

RECORD 1
TITLE
Two cases of late-onset secondary adrenal insufficiency after
discontinuation of nivolumab
AUTHOR NAMES
Otsubo K.
Nakatomi K.
Furukawa R.
Ashida K.
Yoneshima Y.
Nakanishi Y.
Okamoto I.
AUTHOR ADDRESSES
(Otsubo K.; Nakatomi K.; Furukawa R.; Yoneshima Y.; Nakanishi Y.; Okamoto
I., okamotoi@kokyu.med.kyushu-u.ac.jp) Research Institute for Diseases of
the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka,
Japan.
(Ashida K.) Department of Medicine and Bioregulatory Science, Graduate
School of Medical Sciences, Kyushu University, Fukuoka, Japan.
CORRESPONDENCE ADDRESS
I. Okamoto, Research Institute for Diseases of the Chest, Graduate School of
Medical Sciences, Kyushu University, Fukuoka, Japan. Email:
okamotoi@kokyu.med.kyushu-u.ac.jp
SOURCE
Annals of Oncology (2017) 28:12 (3106-3107). Date of Publication: 1 Dec 2017
ISSN
1569-8041 (electronic)
0923-7534
BOOK PUBLISHER
Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
adrenal insufficiency
EMTREE MEDICAL INDEX TERMS
case report
clinical article
drug therapy
drug withdrawal
human
letter
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20180120335
PUI
L620758690
DOI
10.1093/annonc/mdx497
FULL TEXT LINK
http://dx.doi.org/10.1093/annonc/mdx497
COPYRIGHT
Copyright 2018 Elsevier B.V., All rights reserved.

RECORD 2
TITLE
Pembrolizumab is effective for drug-resistant gestational trophoblastic
neoplasia
AUTHOR NAMES
Ghorani E.
Kaur B.
Fisher R.A.
Short D.
Joneborg U.
Carlson J.W.
Akarca A.
Marafioti T.
Quezada S.A.
Sarwar N.
Seckl M.J.
AUTHOR ADDRESSES
(Ghorani E.; Fisher R.A.; Short D.; Sarwar N.; Seckl M.J.,
m.seckl@imperial.ac.uk) Department of Medical Oncology, Charing Cross
Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial
College London, London, United Kingdom.
(Kaur B.) Department of Histopathology, Charing Cross Gestational
Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College
London, London, United Kingdom.
(Ghorani E.; Quezada S.A.) Cancer Immunology Unit, University College London
Cancer Institute, London, United Kingdom.
(Joneborg U.) Department of Women's and Children's Health, Karolinska
Institutet, Karolinska University Hospital, Stockholm, Sweden.
(Carlson J.W.) Department of Oncology-Pathology, Karolinska Institutet,
Karolinska University Hospital, Stockholm, Sweden.
(Akarca A.; Marafioti T.) Department of Cellular Pathology, University
College London Hospital, London, United Kingdom.
SOURCE
The Lancet (2017) 390:10110 (2343-2345). Date of Publication: 25 Nov 2017
ISSN
1474-547X (electronic)
0140-6736
BOOK PUBLISHER
Lancet Publishing Group, cususerv@lancet.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
pembrolizumab (adverse drug reaction, drug therapy, drug toxicity)
EMTREE DRUG INDEX TERMS
CD4 antigen (endogenous compound)
CD56 antigen (endogenous compound)
chorionic gonadotropin (endogenous compound)
HLA G antigen (endogenous compound)
programmed death 1 ligand 1 (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
drug efficacy
trophoblastic tumor (drug therapy, drug resistance, drug therapy, surgery)
EMTREE MEDICAL INDEX TERMS
adjuvant chemotherapy
adult
antigen expression
cancer immunotherapy
cancer recurrence
cancer regression
case report
clinical article
drug tolerability
female
helper cell
human
human tissue
hysterectomy
immunohistochemistry
letter
multiple cycle treatment
priority journal
treatment response
tumor associated leukocyte
unspecified side effect (side effect)
uterus biopsy
CAS REGISTRY NUMBERS
chorionic gonadotropin (9002-61-3)
pembrolizumab (1374853-91-4)
EMBASE CLASSIFICATIONS
Obstetrics and Gynecology (10)
Cancer (16)
Immunology, Serology and Transplantation (26)
Drug Literature Index (37)
Adverse Reactions Titles (38)
General Pathology and Pathological Anatomy (5)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170840145
PUI
L619454330
DOI
10.1016/S0140-6736(17)32894-5
FULL TEXT LINK
http://dx.doi.org/10.1016/S0140-6736(17)32894-5
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 3
TITLE
Case of metastatic uveal melanoma in which an antitumor effect appeared
after ipilimumab discontinuation due to autoimmune hypophysitis
AUTHOR NAMES
Ohnuma T.
Matsuzawa T.
Kinoshita M.
Sano S.
Kawamura T.
Shimada S.
Inozume T.
AUTHOR ADDRESSES
(Ohnuma T.; Matsuzawa T.; Kinoshita M.; Sano S.; Kawamura T.; Shimada S.;
Inozume T., tinozume@yamanashi.ac.jp) Department of Dermatology, University
of Yamanashi, Chuo, Japan.
CORRESPONDENCE ADDRESS
T. Inozume, Department of Dermatology, University of Yamanashi, Chuo, Japan.
Email: tinozume@yamanashi.ac.jp
SOURCE
Journal of Dermatology (2017) 44:11 (1325-1326). Date of Publication: 1 Nov
2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (drug therapy)
EMTREE DRUG INDEX TERMS
hydrocortisone (drug therapy, intravenous drug administration, oral drug
administration)
nivolumab (drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
autoimmune hypophysitis (diagnosis)
metastatic uvea melanoma (drug therapy, drug therapy, surgery)
EMTREE MEDICAL INDEX TERMS
adrenal cortex insufficiency (complication, diagnosis, drug therapy)
adult
case report
clinical article
computer assisted tomography
drug withdrawal
eye surgery
fatigue
female
fever
gastroscopy
human
letter
loss of appetite
lung metastasis
medical history
middle aged
muscle weakness
nuclear magnetic resonance imaging
peritoneum metastasis
CAS REGISTRY NUMBERS
hydrocortisone (50-23-7)
ipilimumab (477202-00-9)
nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
Ophthalmology (12)
Dermatology and Venereology (13)
Cancer (16)
Immunology, Serology and Transplantation (26)
Endocrinology (3)
Drug Literature Index (37)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160910184
PUI
L613684765
DOI
10.1111/1346-8138.13692
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13692
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 4
TITLE
Acute-onset type 1 diabetes mellitus caused by nivolumab in a patient with
advanced pulmonary adenocarcinoma
AUTHOR NAMES
Kumagai R.
Muramatsu A.
Nakajima R.
Fujii M.
Kaino K.
Katakura Y.
Okumura N.
Ohara G.
Kagohashi K.
Satoh H.
Yagyu H.
AUTHOR ADDRESSES
(Kumagai R.; Muramatsu A.; Fujii M.; Kaino K.; Katakura Y.; Yagyu H.,
hiroakiyagyu@aol.com) Department of Endocrinology and Metabolism, Tsukuba
University Hospital Mito Clinical Education and Training Center, Mito Kyodo
General Hospital, Mito, Japan.
(Nakajima R.; Okumura N.) Department of General Medicine, Tsukuba University
Hospital Mito Clinical Education and Training Center, Mito Kyodo General
Hospital, Mito, Japan.
(Ohara G.; Kagohashi K.; Satoh H.) Department of Respiratory Medicine,
Tsukuba University Hospital Mito Clinical Education and Training Center,
Mito Kyodo General Hospital, Mito, Japan.
CORRESPONDENCE ADDRESS
H. Yagyu, Department of Endocrinology and Metabolism, Tsukuba University
Hospital Mito Clinical Education and Training Center, Mito Kyodo General
Hospital, Mito, Japan. Email: hiroakiyagyu@aol.com
SOURCE
Journal of Diabetes Investigation (2017) 8:6 (798-799). Date of Publication:
1 Nov 2017
ISSN
2040-1124 (electronic)
2040-1116
BOOK PUBLISHER
Blackwell Publishing, info@asia.blackpublishing.com.au
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
amylase (endogenous compound)
C peptide (endogenous compound)
glucose (endogenous compound)
hemoglobin A1c (endogenous compound)
HLA DQB1 antigen (endogenous compound)
HLA DRB1 antigen (endogenous compound)
triacylglycerol lipase (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
insulin dependent diabetes mellitus (side effect, diagnosis, side effect)
lung adenocarcinoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
aged
amylase blood level
body weight loss
cancer staging
case report
clinical article
computer assisted tomography
disease exacerbation (side effect)
drug withdrawal
fatigue (side effect)
glucose blood level
glucose tolerance test
hormone blood level
hormone urine level
human
letter
male
pneumonia (side effect)
priority journal
triacylglycerol lipase blood level
urine level
CAS REGISTRY NUMBERS
amylase (9000-90-2, 9000-92-4, 9001-19-8)
C peptide (59112-80-0)
glucose (50-99-7, 84778-64-3)
hemoglobin A1c (62572-11-6)
nivolumab (946414-94-4)
triacylglycerol lipase (9001-62-1)
EMBASE CLASSIFICATIONS
Chest Diseases, Thoracic Surgery and Tuberculosis (15)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170769917
PUI
L619070884
DOI
10.1111/jdi.12627
FULL TEXT LINK
http://dx.doi.org/10.1111/jdi.12627
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 5
TITLE
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with
Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response
AUTHOR NAMES
Marchand L.
Paulus V.
Fabien N.
Pérol M.
Thivolet C.
Vouillarmet J.
Saintigny P.
AUTHOR ADDRESSES
(Marchand L., Lucien.marchand@chu-lyon.fr; Thivolet C.; Vouillarmet J.)
Department of Endocrinology and Diabetes, Hospices Civils de Lyon, Lyon-Sud
Hospital, Pierre-Bénite, France.
(Paulus V.; Pérol M.; Saintigny P.) Department of Medical Oncology, Léon
Bérard Cancer Center, Lyon, France.
(Fabien N.) Department of Immunology, Hospices Civils de Lyon, Lyon-Sud
Hospital, Pierre-Bénite, France.
() Department of Endocrinology and Diabetes, Hospices Civils de Lyon,
Lyon-Sud Hospital, Pierre-Bénite, France.
CORRESPONDENCE ADDRESS
L. Marchand, Department of Endocrinology and Diabetes, Hospices Civils de
Lyon, Lyon-Sud Hospital, 165 chemin du Grand Revoyet, Pierre-Bénite, France.
Email: Lucien.marchand@chu-lyon.fr
SOURCE
Journal of Thoracic Oncology (2017) 12:11 (e182-e184). Date of Publication:
1 Nov 2017
ISSN
1556-1380 (electronic)
1556-0864
BOOK PUBLISHER
Elsevier Inc, agents@lww.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
cisplatin (drug combination, drug therapy)
corticotropin (endogenous compound)
cytokeratin 7 (endogenous compound)
docetaxel (drug combination, drug therapy)
glycosylated hemoglobin (endogenous compound)
hydrocortisone
insulin (drug therapy)
pemetrexed (drug therapy)
programmed death 1 receptor (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
diabetes mellitus (drug therapy, side effect, diagnosis, drug therapy, side
effect)
hypophysitis (side effect, side effect)
non small cell lung cancer (drug therapy, drug therapy)
pulmonary pleomorphic carcinoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
adrenal biopsy
adrenal insufficiency
adrenal tumor
adult
asthenia
case report
clinical article
computer assisted tomography
dysphagia
human
human tissue
hyperglycemia
hyponatremia
hypotension
image guided biopsy
immunohistochemistry
ketoacidosis
letter
maintenance therapy
male
middle aged
multiple cycle treatment
nausea
nose feeding
polydipsia
polyuria
priority journal
smoking
CAS REGISTRY NUMBERS
cisplatin (15663-27-1, 26035-31-4, 96081-74-2)
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
docetaxel (114977-28-5)
glycosylated hemoglobin (9062-63-9)
hydrocortisone (50-23-7)
insulin (9004-10-8)
nivolumab (946414-94-4)
pemetrexed (137281-23-3, 150399-23-8)
EMBASE CLASSIFICATIONS
Chest Diseases, Thoracic Surgery and Tuberculosis (15)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170760092
PUI
L619005390
DOI
10.1016/j.jtho.2017.07.021
FULL TEXT LINK
http://dx.doi.org/10.1016/j.jtho.2017.07.021
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 6
TITLE
Anti-PD-1 Antibody Therapy Induces Hashimoto's Disease with an Increase in
Peripheral Blood Follicular Helper T Cells
AUTHOR NAMES
Torimoto K.
Okada Y.
Nakayamada S.
Kubo S.
Tanaka Y.
AUTHOR ADDRESSES
(Torimoto K.; Okada Y.; Nakayamada S.; Kubo S.; Tanaka Y.,
tanaka@med.uoeh-u.ac.jp) First Department of Internal Medicine, School of
Medicine, University of Occupational and Environmental Health, Japan, 1-1
Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan.
CORRESPONDENCE ADDRESS
Y. Tanaka, First Department of Internal Medicine, School of Medicine,
University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka,
Yahatanishi-ku, Kitakyushu, Japan. Email: tanaka@med.uoeh-u.ac.jp
SOURCE
Thyroid (2017) 27:10 (1335-1336). Date of Publication: 1 Oct 2017
ISSN
1557-9077 (electronic)
1050-7256
BOOK PUBLISHER
Mary Ann Liebert Inc., info@liebertpub.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
programmed death 1 ligand 1 (endogenous compound)
EMTREE DRUG INDEX TERMS
autoantibody (endogenous compound)
levothyroxine (drug therapy)
thyroglobulin antibody (endogenous compound)
thyroid peroxidase antibody (endogenous compound)
thyroid stimulating immunoglobulin (endogenous compound)
thyrotropin (endogenous compound)
thyrotropin receptor antibody (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
blood
Hashimoto disease (side effect, diagnosis, side effect)
Tfh cell
EMTREE MEDICAL INDEX TERMS
adult
cancer chemotherapy
cancer recurrence
case report
clinical article
drug withdrawal
echography
free thyroxine index
human
hypothyroidism (drug therapy)
letter
lung cancer (drug therapy)
male
middle aged
priority journal
Th1 cell
Th17 cell
thyroid function
CAS REGISTRY NUMBERS
levothyroxine (51-48-9)
nivolumab (946414-94-4)
thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
Otorhinolaryngology (11)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170696072
PUI
L618558334
DOI
10.1089/thy.2017.0062
FULL TEXT LINK
http://dx.doi.org/10.1089/thy.2017.0062
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 7
TITLE
Complete serologic response to pembrolizumab in a woman with chemoresistant
metastatic choriocarcinoma
AUTHOR NAMES
Huang M.
Pinto A.
Castillo R.P.
Slomovitz B.M.
AUTHOR ADDRESSES
(Huang M.; Pinto A.; Castillo R.P.; Slomovitz B.M.) University of Miami,
Miami, United States.
SOURCE
Journal of Clinical Oncology (2017) 35:27 (3172-3174). Date of Publication:
20 Sep 2017
ISSN
1527-7755 (electronic)
0732-183X
BOOK PUBLISHER
American Society of Clinical Oncology, jcoservice@asco.org
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
pembrolizumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
carcinoembryonic antigen (endogenous compound)
chorionic gonadotropin (endogenous compound)
chorionic gonadotropin beta subunit (endogenous compound)
cisplatin (drug therapy)
cyclophosphamide (drug combination, drug therapy)
dactinomycin (drug combination, drug therapy)
etoposide (drug combination, drug therapy)
homeobox protein Nkx 2.1 (endogenous compound)
methotrexate (drug combination, drug therapy)
neuroendocrine specific protein (endogenous compound)
progesterone receptor (endogenous compound)
protein (endogenous compound)
protein p63 (endogenous compound)
SAL like protein 4 (endogenous compound)
transcription factor GATA 3 (endogenous compound)
unclassified drug
vincristine (drug combination, drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
cancer resistance
choriocarcinoma (drug therapy, drug resistance, drug therapy)
drug response
EMTREE MEDICAL INDEX TERMS
abdominal mass
abdominal pain
adult
biliary stent
biliary tract disease
brain damage (drug therapy)
case report
clinical article
corticosteroid therapy
down regulation
dyspnea
female
human
human tissue
hypertransaminasemia (side effect)
immunohistochemistry
letter
liver biopsy
liver injury
lung nodule
mediastinum mass
neuroimaging
nuclear magnetic resonance imaging
pancreas disease
priority journal
CAS REGISTRY NUMBERS
chorionic gonadotropin (9002-61-3)
cisplatin (15663-27-1, 26035-31-4, 96081-74-2)
cyclophosphamide (50-18-0)
dactinomycin (1402-38-6, 1402-58-0, 50-76-0)
etoposide (33419-42-0, 433304-61-1)
methotrexate (15475-56-6, 59-05-2, 7413-34-5)
pembrolizumab (1374853-91-4)
protein (67254-75-5)
transcription factor GATA 3 (137878-55-8)
vincristine (57-22-7)
EMBASE CLASSIFICATIONS
Obstetrics and Gynecology (10)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170670152
PUI
L618313655
DOI
10.1200/JCO.2017.74.4052
FULL TEXT LINK
http://dx.doi.org/10.1200/JCO.2017.74.4052
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 8
TITLE
Hypopituitarism and hypothyroidism following atrioventricular block during
nivolumab treatment
AUTHOR NAMES
Oda T.
Sawada Y.
Okada E.
Yamaguchi T.
Ohmori S.
Haruyama S.
Yoshioka M.
Nakamura M.
AUTHOR ADDRESSES
(Oda T.; Sawada Y., long-ago@med.uoeh-u.ac.jp; Okada E.; Yamaguchi T.;
Ohmori S.; Haruyama S.; Yoshioka M.; Nakamura M.) Department of Dermatology,
University of Occupational and Environmental Health, Kitakyushu, Japan.
CORRESPONDENCE ADDRESS
Y. Sawada, Department of Dermatology, University of Occupational and
Environmental Health, Kitakyushu, Japan. Email: long-ago@med.uoeh-u.ac.jp
SOURCE
Journal of Dermatology (2017) 44:6 (e144-e145). Date of Publication: 1 Jun
2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy, intravenous drug
administration, pharmacology)
EMTREE DRUG INDEX TERMS
hydrocortisone (drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
atrioventricular block (side effect, diagnosis, side effect, therapy)
hypopituitarism (side effect, diagnosis, side effect)
hypothyroidism (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
adrenal insufficiency (drug therapy)
aged
case report
computer assisted tomography
fatigue
forehead
histopathology
human
laboratory test
letter
loss of appetite
lung metastasis
male
melanoma (diagnosis, drug therapy)
outcome assessment
patient referral
skin biopsy
skin manifestation (diagnosis)
very elderly
CAS REGISTRY NUMBERS
hydrocortisone (50-23-7)
nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
Cancer (16)
Cardiovascular Diseases and Cardiovascular Surgery (18)
Endocrinology (3)
Clinical and Experimental Pharmacology (30)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170197741
PUI
L614844204
DOI
10.1111/1346-8138.13797
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13797
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 9
TITLE
Immune checkpoint inhibitors-related orchitis
AUTHOR NAMES
Brunet-Possenti F.
Opsomer M.A.
Gomez L.
Ouzaid I.
Descamps V.
AUTHOR ADDRESSES
(Brunet-Possenti F., florence.brunet-possenti@aphp.fr; Descamps V.)
Department of Dermatology, Bichat Claude Bernard Hospital, AP-HP, Paris,
France.
(Opsomer M.A.) Department of Pharmacology, Bichat Claude Bernard Hospital,
AP-HP, Paris, France.
(Gomez L.) Department of Nuclear Medicine, Bichat Claude Bernard Hospital,
AP-HP, Paris, France.
(Ouzaid I.) Department of Urology, Bichat Claude Bernard Hospital, AP-HP,
Paris, France.
CORRESPONDENCE ADDRESS
F. Brunet-Possenti, Department of Dermatology, Bichat Claude Bernard
Hospital, AP-HP, Paris, France. Email: florence.brunet-possenti@aphp.fr
SOURCE
Annals of Oncology (2017) 28:4 (906-907) Article Number: mdw696. Date of
Publication: 1 Apr 2017
ISSN
1569-8041 (electronic)
0923-7534
BOOK PUBLISHER
Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug combination, drug therapy)
nivolumab (adverse drug reaction, drug combination, drug therapy)
EMTREE DRUG INDEX TERMS
fluorodeoxyglucose
luteinizing hormone (endogenous compound)
testosterone (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
orchitis (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
adult
blood examination
bone lesion (diagnosis)
bone metastasis (diagnosis)
cancer combination chemotherapy
cancer localization
cancer staging
case report
clinical examination
drug efficacy
drug infusion
drug tolerability
human
hypogonadism (diagnosis)
immune response
letter
male
melanoma (drug therapy)
middle aged
positron emission tomography
priority journal
scrotal swelling (diagnosis, side effect)
testosterone blood level
treatment response
CAS REGISTRY NUMBERS
fluorodeoxyglucose (29702-43-0)
ipilimumab (477202-00-9)
luteinizing hormone (39341-83-8, 9002-67-9)
nivolumab (946414-94-4)
testosterone (58-22-0)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Nuclear Medicine (23)
Urology and Nephrology (28)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170339657
PUI
L616106162
DOI
10.1093/annonc/mdw696
FULL TEXT LINK
http://dx.doi.org/10.1093/annonc/mdw696
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 10
TITLE
Case of type 1 diabetes associated with less-dose nivolumab therapy in a
melanoma patient
AUTHOR NAMES
Teramoto Y.
Nakamura Y.
Asami Y.
Imamura T.
Takahira S.
Nemoto M.
Sakai G.
Shimada A.
Noda M.
Yamamoto A.
AUTHOR ADDRESSES
(Teramoto Y., y_tera@saitama-med.ac.jp; Nakamura Y.; Asami Y.; Imamura T.;
Yamamoto A.) Department of Skin Oncology/Dermatology, Saitama Medical
University International Medical Center, Saitama, Japan.
(Takahira S.; Nemoto M.) Division of Traumatology and Emergency Acute
Medicine, Saitama Medical University International Medical Center, Saitama,
Japan.
(Sakai G.; Shimada A.; Noda M.) Department of Endocrinology and Diabetes,
Saitama Medical University, Saitama, Japan.
CORRESPONDENCE ADDRESS
Y. Teramoto, Department of Skin Oncology/Dermatology, Saitama Medical
University International Medical Center, Saitama, Japan. Email:
y_tera@saitama-med.ac.jp
SOURCE
Journal of Dermatology (2017) 44:5 (605-606). Date of Publication: 1 May
2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
amylase (endogenous compound)
bicarbonate (endogenous compound)
C peptide (endogenous compound)
dacarbazine (drug therapy)
elastase (endogenous compound)
elastase I (endogenous compound)
glucose (endogenous compound)
hemoglobin A1c (endogenous compound)
insulin (drug therapy)
ketone body (endogenous compound)
unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
cancer immunotherapy
insulin dependent diabetes mellitus (drug therapy, side effect, diagnosis,
drug therapy, side effect)
melanoma (drug therapy, drug therapy)
vulvar melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
adult
amylase blood level
cancer growth
cancer patient
case report
diabetic ketoacidosis (complication, diagnosis)
disease association
drug withdrawal
fatigue (complication)
female
glucose blood level
glycemic control
human
insulin release
insulin treatment
letter
middle aged
pH
polydipsia (complication)
polyuria (complication)
CAS REGISTRY NUMBERS
amylase (9000-90-2, 9000-92-4, 9001-19-8)
bicarbonate (144-55-8, 71-52-3)
C peptide (59112-80-0)
dacarbazine (4342-03-4)
elastase (9004-06-2)
glucose (50-99-7, 84778-64-3)
hemoglobin A1c (62572-11-6)
insulin (9004-10-8)
nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170302735
PUI
L615706972
DOI
10.1111/1346-8138.13486
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13486
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 11
TITLE
Isolated adrenocorticotropic hormone deficiency associated with nivolumab
therapy
AUTHOR NAMES
Narahira A.
Yanagi T.
Cho K.Y.
Nakamura A.
Miyoshi H.
Hata H.
Imafuku K.
Kitamura S.
Shimizu H.
AUTHOR ADDRESSES
(Narahira A.; Yanagi T., yanagi@med.hokudai.ac.jp; Hata H.; Imafuku K.;
Kitamura S.; Shimizu H.) Department of Dermatology, Hokkaido University
Graduate School of Medicine, Sapporo, Japan.
(Cho K.Y.; Nakamura A.; Miyoshi H.) Division of Rheumatology, Endocrinology
and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo,
Japan.
CORRESPONDENCE ADDRESS
T. Yanagi, Department of Dermatology, Hokkaido University Graduate School of
Medicine, Sapporo, Japan. Email: yanagi@med.hokudai.ac.jp
SOURCE
Journal of Dermatology (2017) 44:4 (e70). Date of Publication: 1 Apr 2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
corticotropin (endogenous compound)
corticotropin releasing factor (endogenous compound)
follitropin (endogenous compound)
growth hormone (endogenous compound)
hydrocortisone (drug therapy)
luteinizing hormone (endogenous compound)
prolactin (endogenous compound)
sodium (endogenous compound)
thyrotropin (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
corticotropin deficiency (drug therapy, side effect, drug therapy, side
effect)
isolated ACTH deficiency (drug therapy, side effect, drug therapy, side
effect)
EMTREE MEDICAL INDEX TERMS
aged
anterior pituitary stimulation test
bradykinesia
case report
corticotropin blood level
disease association
endocrine function test
fatigue
female
human
hydrocortisone blood level
hyponatremia
letter
loss of appetite
metastatic melanoma (drug therapy)
multiple cycle treatment
sodium blood level
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
corticotropin releasing factor (9015-71-8, 178359-01-8, 79804-71-0,
86297-72-5, 86784-80-7)
follitropin (9002-68-0)
growth hormone (36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6)
hydrocortisone (50-23-7)
luteinizing hormone (39341-83-8, 9002-67-9)
nivolumab (946414-94-4)
prolactin (12585-34-1, 50647-00-2, 9002-62-4)
sodium (7440-23-5)
thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170258312
PUI
L615243911
DOI
10.1111/1346-8138.13571
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13571
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 12
TITLE
Fulminant type 1 diabetes caused by dual immune checkpoint blockade in
metastatic renal cell carcinoma
AUTHOR NAMES
Teló G.H.
Carvalhal G.F.
Cauduro C.G.S.
Webber V.S.
Barrios C.H.
Fay A.P.
AUTHOR ADDRESSES
(Teló G.H.) Endocrinology Department, Federal University of Rio Grande do
Sul (UFRGS), Porto Alegre, Brazil.
(Carvalhal G.F.; Cauduro C.G.S.; Barrios C.H.; Fay A.P., andre.fay@pucrs.br)
School of Medicine, PUCRS, Porto Alegre, Brazil.
(Webber V.S.; Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Clinical Research
Center, PUCRS, Porto Alegre, Brazil.
(Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Medical Oncology, Hospital do
CâncerMãe de Deus, Porto Alegre, Brazil.
(Barrios C.H.; Fay A.P., andre.fay@pucrs.br) Latin American Cooperative
Oncology Group (LACOG), Porto Alegre, Brazil.
CORRESPONDENCE ADDRESS
A.P. Fay, School of Medicine, PUCRS, Porto Alegre, Brazil. Email:
andre.fay@pucrs.br
SOURCE
Annals of Oncology (2017) 28:1 (191-192). Date of Publication: 1 Jan 2017
ISSN
1569-8041 (electronic)
0923-7534
BOOK PUBLISHER
Oxford University Press, jnl.info@oup.co.uk
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug combination, drug therapy)
nivolumab (adverse drug reaction, drug combination, drug therapy)
EMTREE DRUG INDEX TERMS
triacylglycerol lipase (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
fulminant insulin dependent diabetes mellitus (side effect, diagnosis, side
effect)
insulin dependent diabetes mellitus (side effect, diagnosis, side effect)
kidney carcinoma (drug therapy, drug therapy)
metastasis (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
adult
case report
computer assisted tomography
confusion
diabetic ketoacidosis
drug response
fatigue
fever
flu like syndrome
glycemic control
human
hyperglycemia
ketoacidosis
letter
male
middle aged
pancreatitis (diagnosis)
pneumonia
polydipsia
polyuria
triacylglycerol lipase blood level
CAS REGISTRY NUMBERS
ipilimumab (477202-00-9)
nivolumab (946414-94-4)
triacylglycerol lipase (9001-62-1)
EMBASE CLASSIFICATIONS
Cancer (16)
Urology and Nephrology (28)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
Internal Medicine (6)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170214180
PUI
L614949602
DOI
10.1093/annonc/mdw447
FULL TEXT LINK
http://dx.doi.org/10.1093/annonc/mdw447
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 13
TITLE
A case of fulminant type 1 diabetes mellitus, with a precipitous decrease in
pancreatic volume, induced by nivolumab for malignant melanoma: Analysis of
HLA and CTLA-4 polymorphisms
AUTHOR NAMES
Ishikawa K.
Shono-Saito T.
Yamate T.
Kai Y.
Sakai T.
Shimizu F.
Yamada Y.
Mori H.
Noso S.
Ikegami H.
Kojima H.
Tanaka H.
Fujiwara S.
Hatano Y.
AUTHOR ADDRESSES
(Ishikawa K.; Shono-Saito T.; Yamate T.; Kai Y.; Sakai T.; Fujiwara S.;
Hatano Y., hatano@oita-u.ac.jp) Department of Dermatology, Faculty of
Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Shimizu F.) Department of Plastic Surgery, Faculty of Medicine, Oita
University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Yamada Y.; Mori H.) Department of Radiology, Faculty of Medicine, Oita
University, 1-1 Idaigaoka, Hasama-machi, Yufu, Japan.
(Noso S.; Ikegami H.) Department of Endocrinology Metabolism and Diabetes,
Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama,
Osaka, Japan.
(Kojima H.; Tanaka H.) HLA Foundation Laboratory, Kyoto, Japan.
CORRESPONDENCE ADDRESS
Y. Hatano, Department of Dermatology, Faculty of Medicine, Oita University,
1-1 Idaigaoka, Hasama-machi, Yufu, Japan. Email: hatano@oita-u.ac.jp
SOURCE
European Journal of Dermatology (2017) 27:2 (184-185). Date of Publication:
2017
ISSN
1952-4013 (electronic)
1167-1122
BOOK PUBLISHER
John Libbey Eurotext, 127, avenue de la Republique, Montrouge, France.
contact@jle.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
cytotoxic T lymphocyte antigen 4 (endogenous compound)
HLA antigen (endogenous compound)
nivolumab (drug therapy)
EMTREE DRUG INDEX TERMS
B Raf kinase (endogenous compound)
cysteinyldopa
hemoglobin A1c (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
fulminant insulin dependent diabetes mellitus (diagnosis)
insulin dependent diabetes mellitus (diagnosis)
melanoma (drug therapy, diagnosis, drug therapy)
organ size
pancreatic volume
EMTREE MEDICAL INDEX TERMS
adipose tissue
adult
blood sampling
breslow thickness
cancer chemotherapy
case report
computer assisted tomography
cytotoxic T lymphocyte antigen 4 gene
female
gene
genotype
HLA antigen gene
human
hyperglycemia
insulin treatment
letter
lymph node metastasis
middle aged
oncological parameters
polydipsia
single nucleotide polymorphism
CAS REGISTRY NUMBERS
cysteinyldopa (19641-92-0)
hemoglobin A1c (62572-11-6)
nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
Cancer (16)
Human Genetics (22)
Drug Literature Index (37)
Internal Medicine (6)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170284969
PUI
L615491345
DOI
10.1684/ejd.2016.2923
FULL TEXT LINK
http://dx.doi.org/10.1684/ejd.2016.2923
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 14
TITLE
Isolated adrenocorticotropic hormone deficiency possibly caused by nivolumab
in a metastatic melanoma patient
AUTHOR NAMES
Fujimura T.
Kambayashi Y.
Furudate S.
Kakizaki A.
Hidaka T.
Haga T.
Hashimoto A.
Morimoto R.
Aiba S.
AUTHOR ADDRESSES
(Fujimura T., tfujimura1@mac.com; Kambayashi Y.; Furudate S.; Kakizaki A.;
Hidaka T.; Haga T.; Hashimoto A.; Aiba S.) Department of Dermatology, Tohoku
University Graduate School of Medicine, Sendai, Japan.
(Morimoto R.) Division of Nephrology, Endocrinology and Vascular Medicine,
Department of Medicine, Tohoku University Hospital, Sendai, Japan.
CORRESPONDENCE ADDRESS
T. Fujimura, Department of Dermatology, Tohoku University Graduate School of
Medicine, Sendai, Japan. Email: tfujimura1@mac.com
SOURCE
Journal of Dermatology (2017) 44:3 (e13-e14). Date of Publication: 1 Mar
2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
CD163 antigen (endogenous compound)
corticotropin (endogenous compound)
epithelial derived neutrophil activating factor 78 (endogenous compound)
thyrotropin (endogenous compound)
tumor necrosis factor (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
corticotropin deficiency (side effect, diagnosis, side effect)
metastatic melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
acral lentiginous melanoma (surgery)
aged
brain metastasis (diagnosis, radiotherapy)
case report
cutaneous melanoma (surgery)
CyberKnife
human
human tissue
hypopituitarism
letter
male
nuclear magnetic resonance imaging
skin nodule
thyrotropin blood level
DEVICE TRADE NAMES
CyberKnife , United StatesAccuray

DEVICE MANUFACTURERS
(United States)Accuray
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
epithelial derived neutrophil activating factor 78 (136956-40-6)
nivolumab (946414-94-4)
thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Biophysics, Bioengineering and Medical Instrumentation (27)
Urology and Nephrology (28)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160553134
PUI
L611375839
DOI
10.1111/1346-8138.13532
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13532
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 15
TITLE
Hyponatremia can be a powerful predictor of the development of isolated ACTH
deficiency associated with nivolumab treatment
AUTHOR NAMES
Cho K.Y.
Miyoshi H.
Nakamura A.
Kurita T.
Atsumi T.
AUTHOR ADDRESSES
(Cho K.Y., kyuyong-cho@med.hokudai.ac.jp; Miyoshi H.; Nakamura A.; Atsumi
T.) Division of Rheumatology, Endocrinology and Nephrology, Hokkaido
University Graduate School of Medicine, Sapporo, Japan.
(Kurita T.) Department of Internal Medicine, Japanese Red Cross Kitami
Hospital, Kitami, Japan.
CORRESPONDENCE ADDRESS
K.Y. Cho, Division of Rheumatology, Endocrinology and Nephrology, Hokkaido
University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo,
Hokkaido, Japan. Email: kyuyong-cho@med.hokudai.ac.jp
SOURCE
Endocrine Journal (2017) 64:2 (235-236). Date of Publication: 2017
ISSN
1348-4540 (electronic)
0918-8959
BOOK PUBLISHER
Japan Endocrine Society, endo-soc-japan@ml.infoweb.ne.jp
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
corticotropin (endogenous compound)
hydrocortisone (drug therapy, endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
corticotropin deficiency (drug therapy, side effect, diagnosis, drug
therapy, side effect)
disease course
hyponatremia (side effect, diagnosis, side effect)
prediction
EMTREE MEDICAL INDEX TERMS
adult
aged
case report
corticotropin blood level
drug safety
endocrine function test
fatigue (side effect)
female
hormone substitution
human
hydrocortisone blood level
hydrocortisone release
hypotension
laboratory test
letter
loss of appetite (side effect)
male
melanoma (drug therapy)
middle aged
nausea (side effect)
non small cell lung cancer (drug therapy)
pain (side effect)
treatment response
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
hydrocortisone (50-23-7)
nivolumab (946414-94-4)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Clinical and Experimental Biochemistry (29)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170156969
PUI
L614613118
DOI
10.1507/endocrj.EJ16-0596
FULL TEXT LINK
http://dx.doi.org/10.1507/endocrj.EJ16-0596
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 16
TITLE
Hypothyroidism associated with nivolumab treatment of unresectable malignant
melanoma
AUTHOR NAMES
Imafuku K.
Yoshino K.
Yamaguchi K.
Tsuboi S.
Ohara K.
Hata H.
AUTHOR ADDRESSES
(Imafuku K., imafukukeisuke@gmail.com; Yoshino K.; Yamaguchi K.; Tsuboi S.;
Ohara K.) Department of Dermatology, Tokyo Metropolitan Cancer and
Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagoame,
Bunkyo-ku, Tokyo, Tokyo, Japan.
(Hata H.) Department of Dermatology, Hokkaido University Graduate School of
Medicine, Sapporo, Japan.
SOURCE
Clinical and Experimental Dermatology (2017) 42:2 (217-218). Date of
Publication: 1 Mar 2017
ISSN
1365-2230 (electronic)
0307-6938
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
thyroid hormone (drug therapy)
thyrotropin (endogenous compound)
thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
drug induced disease (drug therapy, side effect, drug therapy, side effect)
hypothyroidism (drug therapy, side effect, drug therapy, side effect)
inoperable cancer (drug therapy, drug therapy)
melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
aged
cancer immunotherapy
case report
disease exacerbation
drug withdrawal
heart failure
hormonal therapy
human
letter
male
multiple cycle treatment
patient care
priority journal
thyrotropin blood level
thyroxine blood level
CAS REGISTRY NUMBERS
nivolumab (946414-94-4)
thyrotropin (9002-71-5)
thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170052142
MEDLINE PMID
28052364 (http://www.ncbi.nlm.nih.gov/pubmed/28052364)
PUI
L614107353
DOI
10.1111/ced.13028
FULL TEXT LINK
http://dx.doi.org/10.1111/ced.13028
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 17
TITLE
Autoimmune diabetes superimposed on type 2 diabetes in a patient initiated
on immunotherapy for lung cancer
AUTHOR NAMES
Alhusseini M.
Samantray J.
AUTHOR ADDRESSES
(Alhusseini M., malhusse@med.wayne.edu; Samantray J.) Department of Internal
Medicine, Division of Endocrinology, Detroit Medical Center, Wayne State
University School of Medicine, University Health Center, 4201 St. Antoine,
Suite 4H, Detroit, United States.
CORRESPONDENCE ADDRESS
M. Alhusseini, Department of Internal Medicine, Division of Endocrinology,
Detroit Medical Center, Wayne State University School of Medicine,
University Health Center, 4201 St. Antoine, Suite 4H, Detroit, United
States. Email: malhusse@med.wayne.edu
SOURCE
Diabetes and Metabolism (2017) 43:1 (86-88). Date of Publication: 1 Feb 2017
ISSN
1878-1780 (electronic)
1262-3636
BOOK PUBLISHER
Elsevier Masson SAS, 62 rue Camille Desmoulins, Issy les Moulineaux Cedex,
France.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, clinical trial, drug therapy)
pembrolizumab (adverse drug reaction, clinical trial, drug therapy)
EMTREE DRUG INDEX TERMS
C peptide (endogenous compound)
glimepiride (drug combination, drug therapy)
glucose (endogenous compound)
glutamate decarboxylase 65 (endogenous compound)
hemoglobin A1c (endogenous compound)
levothyroxine (drug therapy)
metformin (drug combination, drug therapy)
thyroid peroxidase antibody (endogenous compound)
thyroid stimulating immunoglobulin (endogenous compound)
thyrotropin (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
cancer immunotherapy
latent autoimmune diabetes in adults (side effect, side effect)
lung adenocarcinoma (drug therapy, drug therapy, therapy)
non insulin dependent diabetes mellitus (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
aged
anion gap
asymptomatic disease
case report
diabetic ketoacidosis
drug withdrawal
follow up
free thyroxine index
glucose blood level
human
hyperthyroidism (drug therapy)
hypothyroidism
insulin treatment
letter
male
thyroiditis
tumor volume
vomiting
CAS REGISTRY NUMBERS
C peptide (59112-80-0)
glimepiride (93479-97-1)
glucose (50-99-7, 84778-64-3)
hemoglobin A1c (62572-11-6)
ipilimumab (477202-00-9)
levothyroxine (51-48-9)
metformin (1115-70-4, 657-24-9)
pembrolizumab (1374853-91-4)
thyrotropin (9002-71-5)
EMBASE CLASSIFICATIONS
Chest Diseases, Thoracic Surgery and Tuberculosis (15)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
Internal Medicine (6)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160936975
MEDLINE PMID
27291328 (http://www.ncbi.nlm.nih.gov/pubmed/27291328)
PUI
L613819714
DOI
10.1016/j.diabet.2016.05.007
FULL TEXT LINK
http://dx.doi.org/10.1016/j.diabet.2016.05.007
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 18
TITLE
Ipilimumab-induced hypophysitis and ileocolitis: Serial pituitary MRI
findings
AUTHOR NAMES
Singh D.
Hsu C.C.-T.
Kwan G.N.C.
Bhuta S.
AUTHOR ADDRESSES
(Singh D., dsingh1386@gmail.com) Department of Medical Imaging, School of
Medicine, University of Queensland, Brisbane, Australia.
(Hsu C.C.-T.; Kwan G.N.C.; Bhuta S.) Department of Medical Imaging, Gold
Coast University Hospital, Southport, Australia.
CORRESPONDENCE ADDRESS
D. Singh, Department of Medical Imaging, School of Medicine, University of
Queensland, Brisbane, Australia. Email: dsingh1386@gmail.com
SOURCE
Neurology India (2017) 65:1 (165-166). Date of Publication: 1 Jan 2017
ISSN
1998-4022 (electronic)
0028-3886
BOOK PUBLISHER
Medknow Publications, B9, Kanara Business Centre, off Link Road, Ghatkopar
(E), Mumbai, India.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
corticotropin (endogenous compound)
dexamethasone (drug combination, drug dose, drug therapy)
follitropin (endogenous compound)
hydrocortisone (endogenous compound)
luteinizing hormone (endogenous compound)
prednisone (drug combination, drug dose, drug therapy)
prolactin (endogenous compound)
testosterone (endogenous compound)
testosterone undecanoate (intramuscular drug administration)
thyrotropin (endogenous compound)
thyroxine (drug therapy, endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
colitis (drug therapy, side effect, diagnosis, drug therapy, side effect)
hypophysitis (drug therapy, side effect, diagnosis, drug therapy, side
effect)
ileum disease (drug therapy, side effect, diagnosis, drug therapy, side
effect)
nuclear magnetic resonance imaging
EMTREE MEDICAL INDEX TERMS
abdominal pain
adult
case report
colon biopsy
computer assisted tomography
contrast enhancement
diarrhea
disease severity
drug megadose
drug withdrawal
granulomatous inflammation (diagnosis)
headache
histopathology
human
human cell
human tissue
hypothyroidism (diagnosis, drug therapy)
laboratory test
letter
male
melanoma (drug therapy)
middle aged
migraine
nausea
neurologic examination
pain severity
sigmoidoscopy
vertigo
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
dexamethasone (50-02-2)
follitropin (9002-68-0)
hydrocortisone (50-23-7)
ipilimumab (477202-00-9)
luteinizing hormone (39341-83-8, 9002-67-9)
prednisone (53-03-2)
prolactin (12585-34-1, 50647-00-2, 9002-62-4)
testosterone (58-22-0)
testosterone undecanoate (5949-44-0)
thyrotropin (9002-71-5)
thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
Gastroenterology (48)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20170063651
PUI
L614160211
DOI
10.4103/0028-3886.198182
FULL TEXT LINK
http://dx.doi.org/10.4103/0028-3886.198182
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 19
TITLE
Case of hypophysitis caused by nivolumab
AUTHOR NAMES
Ishikawa M.
Oashi K.
AUTHOR ADDRESSES
(Ishikawa M., m-ishikawa@cancer-c.pref.saitama.jp; Oashi K.) Department of
Dermatology, Saitama Cancer Center, Saitama, Japan.
CORRESPONDENCE ADDRESS
M. Ishikawa, Department of Dermatology, Saitama Cancer Center, Saitama,
Japan. Email: m-ishikawa@cancer-c.pref.saitama.jp
SOURCE
Journal of Dermatology (2017) 44:1 (109-110). Date of Publication: 1 Jan
2017
ISSN
1346-8138 (electronic)
0385-2407
BOOK PUBLISHER
Blackwell Publishing Ltd, customerservices@oxonblackwellpublishing.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
nivolumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
corticotropin (endogenous compound)
dacarbazine (drug therapy)
hydrocortisone (drug therapy, endogenous compound, oral drug administration)
hydrocortisone sodium succinate (drug combination, drug therapy)
oxygen (drug combination, drug therapy, inhalational drug administration)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
hypophysitis (drug therapy, side effect, diagnosis, drug therapy, side
effect)
EMTREE MEDICAL INDEX TERMS
adrenal insufficiency (drug therapy)
adrenal metastasis
adult
anorexia
body weight loss
case report
depressed blood pressure
drug dose increase
drug withdrawal
human
hypothyroidism (side effect)
infusion related reaction (drug therapy, side effect)
interstitial pneumonia (side effect)
letter
malaise
male
melanoma (drug therapy)
middle aged
multiple cycle treatment
myalgia
nausea
nuclear magnetic resonance imaging
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
dacarbazine (4342-03-4)
hydrocortisone (50-23-7)
hydrocortisone sodium succinate (125-04-2, 2203-97-6)
nivolumab (946414-94-4)
oxygen (7782-44-7)
EMBASE CLASSIFICATIONS
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
Neurology and Neurosurgery (8)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160405458
MEDLINE PMID
27178147 (http://www.ncbi.nlm.nih.gov/pubmed/27178147)
PUI
L610556665
DOI
10.1111/1346-8138.13437
FULL TEXT LINK
http://dx.doi.org/10.1111/1346-8138.13437
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 20
TITLE
Pituitary Dysfunction: A Case Series of Immune Checkpoint Inhibitor–Related
Hypophysitis in an Emergency Department
AUTHOR NAMES
Miller A.H.
Brock P.
Jim Yeung S.-C.
AUTHOR ADDRESSES
(Miller A.H.; Brock P.; Jim Yeung S.-C.) Department of Emergency Medicine,
University of Texas MD Anderson Cancer Center, Houston, United States.
SOURCE
Annals of Emergency Medicine (2016) 68:2 (249-250). Date of Publication: 1
Aug 2016
ISSN
1097-6760 (electronic)
0196-0644
BOOK PUBLISHER
Mosby Inc., customerservice@mosby.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
antineoplastic agent (drug therapy)
immune checkpoint inhibitor (drug therapy)
immunomodulating agent (drug therapy)
EMTREE DRUG INDEX TERMS
glucocorticoid (drug therapy)
hydrocortisone sodium succinate (drug therapy, intravenous drug
administration)
ipilimumab (adverse drug reaction)
prolactin (endogenous compound)
unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
hypophysitis (drug therapy, side effect, drug therapy, side effect)
EMTREE MEDICAL INDEX TERMS
adrenal insufficiency
blood pressure regulation
cancer chemotherapy
drug megadose
emergency physician
emergency ward
human
hyponatremia
hypopituitarism
hypothyroidism
letter
nuclear magnetic resonance imaging
priority journal
prolactin blood level
CAS REGISTRY NUMBERS
hydrocortisone sodium succinate (125-04-2, 2203-97-6)
ipilimumab (477202-00-9)
prolactin (12585-34-1, 50647-00-2, 9002-62-4)
EMBASE CLASSIFICATIONS
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160874514
PUI
L613479098
DOI
10.1016/j.annemergmed.2016.03.048
FULL TEXT LINK
http://dx.doi.org/10.1016/j.annemergmed.2016.03.048
COPYRIGHT
Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 21
TITLE
Late-onset panhypopituitarism in a 72-year-old male patient treated with
ipilimumab for metastatic melanoma: a case report
AUTHOR NAMES
Vancieri G.
Bellia A.
Lauro D.
AUTHOR ADDRESSES
(Vancieri G.; Bellia A.; Lauro D., d.lauro@med.uniroma2.it) Division of
Endocrinology and Diabetology, Department of Systems Medicine, University of
Rome “Tor Vergata”, Rome, Italy.
CORRESPONDENCE ADDRESS
D. Lauro, Division of Endocrinology and Diabetology, Department of Systems
Medicine, University of Rome “Tor Vergata”, Rome, Italy. Email:
d.lauro@med.uniroma2.it
SOURCE
Journal of Endocrinological Investigation (2016) 39:7 (805-806). Date of
Publication: 1 Jul 2016
ISSN
1720-8386 (electronic)
0391-4097
BOOK PUBLISHER
Springer International Publishing
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
corticotropin (endogenous compound)
cortisone acetate (drug therapy)
dipeptidyl carboxypeptidase inhibitor
hydrochlorothiazide
hydrocortisone (endogenous compound)
levothyroxine (drug therapy)
luteinizing hormone (endogenous compound)
prolactin (endogenous compound)
somatomedin C (endogenous compound)
testosterone (endogenous compound)
testosterone enantate (drug therapy)
thyrotropin (endogenous compound)
thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
autoimmune hypophysitis (side effect, side effect)
hypopituitarism (drug therapy, side effect, drug therapy, side effect)
metastatic melanoma (drug therapy, drug therapy)
EMTREE MEDICAL INDEX TERMS
aged
antihypertensive therapy
cancer immunotherapy
case report
computer assisted tomography
corticotropin blood level
electrocardiogram
emergency ward
fatigue
hormone substitution
human
hydrocortisone blood level
Italian (citizen)
letter
luteinizing hormone blood level
male
new-onset atrial fibrillation
nuclear magnetic resonance imaging
presyncope
prolactin blood level
testosterone blood level
thyrotropin blood level
thyroxine blood level
CAS REGISTRY NUMBERS
corticotropin (11136-52-0, 9002-60-2, 9061-27-2)
cortisone acetate (50-04-4)
hydrochlorothiazide (58-93-5)
hydrocortisone (50-23-7)
ipilimumab (477202-00-9)
levothyroxine (51-48-9)
luteinizing hormone (39341-83-8, 9002-67-9)
prolactin (12585-34-1, 50647-00-2, 9002-62-4)
somatomedin C (67763-96-6)
testosterone (58-22-0)
testosterone enantate (315-37-7)
thyrotropin (9002-71-5)
thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
Cancer (16)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160478209
MEDLINE PMID
26883763 (http://www.ncbi.nlm.nih.gov/pubmed/26883763)
PUI
L610967362
DOI
10.1007/s40618-016-0439-3
FULL TEXT LINK
http://dx.doi.org/10.1007/s40618-016-0439-3
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 22
TITLE
A case report of insulin-dependent diabetes as immune-related toxicity of
pembrolizumab: presentation, management and outcome
AUTHOR NAMES
Hansen E.
Sahasrabudhe D.
Sievert L.
AUTHOR ADDRESSES
(Hansen E., Elizabeth_hansen@urmc.rochester.edu; Sahasrabudhe D.; Sievert
L.) University of Rochester Medical Center, 601 Elmwood Avenue, Box 617,
Rochester, United States.
CORRESPONDENCE ADDRESS
E. Hansen, University of Rochester Medical Center, 601 Elmwood Avenue, Box
617, Rochester, United States. Email: Elizabeth_hansen@urmc.rochester.edu
SOURCE
Cancer Immunology, Immunotherapy (2016) 65:6 (765-767). Date of Publication:
1 Jun 2016
ISSN
1432-0851 (electronic)
0340-7004
BOOK PUBLISHER
Springer Science and Business Media Deutschland GmbH, info@springer-sbm.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
pembrolizumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
alpha2b interferon (drug therapy)
B Raf kinase (endogenous compound)
C peptide (endogenous compound)
dabrafenib (drug combination, drug therapy)
glucose (endogenous compound)
glutamate decarboxylase antibody (endogenous compound)
hemoglobin A1c (endogenous compound)
interleukin 2 (drug combination, drug therapy)
ipilimumab (drug combination, drug therapy)
long acting insulin (drug therapy)
short acting insulin (drug therapy)
trametinib (drug combination, drug therapy)
vemurafenib (drug combination, drug therapy)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
immunotoxicity (side effect, side effect)
insulin dependent diabetes mellitus (drug therapy, side effect, diagnosis,
drug therapy, side effect)
EMTREE MEDICAL INDEX TERMS
adult
axillary lymph node
body weight disorder (side effect)
body weight gain
body weight loss
cancer adjuvant therapy
cancer combination chemotherapy
cancer staging
cancer surgery
case report
compassionate use
cutaneous melanoma (drug therapy, surgery)
drug megadose
drug withdrawal
fatigue (side effect)
gastroesophageal reflux (side effect)
gene mutation
glucose blood level
hair discoloration (side effect)
human
hypothyroidism (side effect)
letter
liver tumor (drug therapy)
lung biopsy
lymph node dissection
lymphadenopathy
male
metastatic melanoma (drug therapy)
middle aged
polydipsia
polyuria
priority journal
rash
tumor biopsy
wide excision
CAS REGISTRY NUMBERS
alpha2b interferon (99210-65-8)
C peptide (59112-80-0)
dabrafenib (1195765-45-7, 1195768-06-9)
glucose (50-99-7, 84778-64-3)
hemoglobin A1c (62572-11-6)
interleukin 2 (85898-30-2)
ipilimumab (477202-00-9)
pembrolizumab (1374853-91-4)
trametinib (1187431-43-1, 871700-17-3)
vemurafenib (918504-65-1)
EMBASE CLASSIFICATIONS
Dermatology and Venereology (13)
Cancer (16)
Immunology, Serology and Transplantation (26)
Clinical and Experimental Biochemistry (29)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160294004
MEDLINE PMID
27067877 (http://www.ncbi.nlm.nih.gov/pubmed/27067877)
PUI
L609833201
DOI
10.1007/s00262-016-1835-4
FULL TEXT LINK
http://dx.doi.org/10.1007/s00262-016-1835-4
COPYRIGHT
Copyright 2017 Elsevier B.V., All rights reserved.

RECORD 23
TITLE
Determining predictive factors for immune checkpoint inhibitor toxicity:
Response to Letter to the Editors “A case report of insulin-dependent
diabetes as immune-related toxicity of pembrolizumab: presentation,
management and outcome”
AUTHOR NAMES
Spain L.
Larkin J.
Martin-Liberal J.
AUTHOR ADDRESSES
(Spain L.; Larkin J.) Melanoma Unit, Royal Marsden NHS Foundation Trust,
Fulham Road, London, United Kingdom.
(Martin-Liberal J., jmartinliberal@gmail.com) Department of Medical
Oncology, Vall d’Hebron University Hospital, Vall d’Hebron Institute of
Oncology (VHIO), Pg Vall d’Hebron, 119-129, Barcelona, Spain.
CORRESPONDENCE ADDRESS
J. Martin-Liberal, Department of Medical Oncology, Vall d’Hebron University
Hospital, Vall d’Hebron Institute of Oncology (VHIO), Pg Vall d’Hebron,
119-129, Barcelona, Spain. Email: jmartinliberal@gmail.com
SOURCE
Cancer Immunology, Immunotherapy (2016) 65:6 (769-770). Date of Publication:
1 Jun 2016
ISSN
1432-0851 (electronic)
0340-7004
BOOK PUBLISHER
Springer Science and Business Media Deutschland GmbH, info@springer-sbm.com
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
pembrolizumab (adverse drug reaction)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
immunotoxicity (side effect, side effect)
insulin dependent diabetes mellitus (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
colitis
disease association
disease course
genotype
HLA typing
human
insulin dependence
letter
outcome assessment
predictive value
priority journal
CAS REGISTRY NUMBERS
pembrolizumab (1374853-91-4)
EMBASE CLASSIFICATIONS
Immunology, Serology and Transplantation (26)
Endocrinology (3)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
20160390796
PUI
L610481095
DOI
10.1007/s00262-016-1845-2
FULL TEXT LINK
http://dx.doi.org/10.1007/s00262-016-1845-2
COPYRIGHT
Copyright 2016 Elsevier B.V., All rights reserved.

RECORD 24
TITLE
Ipilimumab-induced hypophysitis: Early Australian experience
AUTHOR NAMES
De Sousa S.M.C.
Long G.V.
Tonks K.T.
AUTHOR ADDRESSES
(De Sousa S.M.C.) Department of Endocrinology, St Vincent's Hospital,
Sydney, NSW, Australia.
(Long G.V.) Melanoma Institute Australia, Sydney, NSW, Australia.
(Tonks K.T.) Diabetes and Metabolism Division, Garvan Institute of Medical
Research, Sydney, NSW, Australia.
SOURCE
Medical Journal of Australia (2014) 201:4 (198-199). Date of Publication: 18
Aug 2014
ISSN
1326-5377 (electronic)
0025-729X
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
cytotoxic T lymphocyte antigen 4 (endogenous compound)
dexamethasone
follitropin (endogenous compound)
hydrocortisone (endogenous compound)
liothyronine (endogenous compound)
prednisolone
testosterone (endogenous compound)
thyrotropin (endogenous compound)
thyroxine (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
hypophysitis (side effect, diagnosis, side effect)
EMTREE MEDICAL INDEX TERMS
adult
androgen therapy
anorexia
asthenia
case report
cell proliferation
dizziness
drug dose reduction
drug megadose
fatigue
headache
human
hypogonadism
insulin tolerance test
letter
lumbar puncture
male
metastatic melanoma (drug therapy)
nuclear magnetic resonance imaging
T lymphocyte activation
tumor growth
vomiting
CAS REGISTRY NUMBERS
dexamethasone (50-02-2)
follitropin (9002-68-0)
hydrocortisone (50-23-7)
ipilimumab (477202-00-9)
liothyronine (6138-47-2, 6893-02-3)
prednisolone (50-24-8)
testosterone (58-22-0)
thyrotropin (9002-71-5)
thyroxine (7488-70-2)
EMBASE CLASSIFICATIONS
Cancer (16)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2014554713
MEDLINE PMID
25164840 (http://www.ncbi.nlm.nih.gov/pubmed/25164840)
PUI
L373790824
DOI
10.5694/mja14.00803
FULL TEXT LINK
http://dx.doi.org/10.5694/mja14.00803
COPYRIGHT
Copyright 2015 Elsevier B.V., All rights reserved.

RECORD 25
TITLE
Ipilimumab-induced orbital inflammation resembling graves disease with
subsequent development of systemic hyperthyroidism from CTLA-4 receptor
suppression
AUTHOR NAMES
Borodic G.E.
Hinkle D.
AUTHOR ADDRESSES
(Borodic G.E., borodic@aol.com; Hinkle D.)
CORRESPONDENCE ADDRESS
G.E. Borodic, Harvard Medical School, 1261 Furance Brook Parkway, Quincy,
MA, United States. Email: borodic@aol.com
SOURCE
Ophthalmic Plastic and Reconstructive Surgery (2014) 30:1 (83). Date of
Publication: January-February 2014
ISSN
0740-9303
1537-2677 (electronic)
BOOK PUBLISHER
Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327,
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
cytotoxic T lymphocyte antigen 4 (endogenous compound)
ipilimumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
liothyronine (endogenous compound)
thyroglobulin antibody (endogenous compound)
thyroid antibody (endogenous compound)
thyroid peroxidase antibody (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
Graves disease
hyperthyroidism
orbit inflammation (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
anxiety
body weight loss
diarrhea (side effect)
disease course
heart palpitation (side effect)
heat intolerance (side effect)
human
lethargy (side effect)
letter
liothyronine blood level
priority journal
unspecified side effect (side effect)
CAS REGISTRY NUMBERS
ipilimumab (477202-00-9)
liothyronine (6138-47-2, 6893-02-3)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Ophthalmology (12)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2014071521
MEDLINE PMID
24398505 (http://www.ncbi.nlm.nih.gov/pubmed/24398505)
PUI
L372204569
DOI
10.1097/IOP.0000000000000033
FULL TEXT LINK
http://dx.doi.org/10.1097/IOP.0000000000000033
COPYRIGHT
Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 26
TITLE
Immune-mediated colitis: Important to recognize and treat
AUTHOR NAMES
Pocha C.
Roat J.
Viskocil K.
AUTHOR ADDRESSES
(Pocha C., Pocha004@umn.edu; Roat J.; Viskocil K.) University of Minnesota,
Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, United
States.
CORRESPONDENCE ADDRESS
C. Pocha, University of Minnesota, Minneapolis Veterans Affairs Health Care
System, Minneapolis, MN, United States. Email: Pocha004@umn.edu
SOURCE
Journal of Crohn's and Colitis (2014) 8:2 (181-182). Date of Publication: 1
Feb 2014
ISSN
1873-9946
1876-4479 (electronic)
BOOK PUBLISHER
Elsevier, P.O. Box 211, Amsterdam, Netherlands.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
hydrocortisone
infliximab (drug therapy, intravenous drug administration)
methylprednisolone (intravenous drug administration)
prednisone (oral drug administration)
testosterone
thyroid hormone
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
hypophysitis (side effect, side effect)
immunopathology (side effect, side effect)
pancolitis (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
adrenal insufficiency (complication)
aged
anorexia (side effect)
bloody diarrhea
cancer chemotherapy
case report
colon ulcer
colonoscopy
diarrhea (drug therapy, side effect)
disease severity
edema
erythema
fatigue (side effect)
hormone substitution
human
hypopituitarism (complication)
hypothyroidism (complication)
lamina propria
letter
lymphocyte
male
metastatic melanoma (drug therapy)
microscopy
multiple cycle treatment
neutrophil
priority journal
steroid therapy
DRUG TRADE NAMES
yervoy
CAS REGISTRY NUMBERS
hydrocortisone (50-23-7)
infliximab (170277-31-3)
ipilimumab (477202-00-9)
methylprednisolone (6923-42-8, 83-43-2)
prednisone (53-03-2)
testosterone (58-22-0)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Immunology, Serology and Transplantation (26)
Drug Literature Index (37)
Adverse Reactions Titles (38)
Gastroenterology (48)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2014062485
MEDLINE PMID
24138785 (http://www.ncbi.nlm.nih.gov/pubmed/24138785)
PUI
L52813186
DOI
10.1016/j.crohns.2013.09.019
FULL TEXT LINK
http://dx.doi.org/10.1016/j.crohns.2013.09.019
COPYRIGHT
Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 27
TITLE
Ipilimumab, a cause of autoimmune hypophysitis
ORIGINAL (NON-ENGLISH) TITLE
Ipilimumab, una causa de hipofisitis autoinmunitaria
AUTHOR NAMES
De Hollanda A.
Aranda G.B.
Mora M.
Gaba L.
Halperin I.
AUTHOR ADDRESSES
(De Hollanda A., amdehol@clinic.ub.es; Aranda G.B.; Mora M.; Halperin I.)
Servicio de Endocrinología y Nutrición, Hospital Clínic, Universitat de
Barcelona, Barcelona, Spain.
(Gaba L.) Servicio de Oncología, Hospital Clínic, Universitat de Barcelona,
Barcelona, Spain.
CORRESPONDENCE ADDRESS
A. De Hollanda, Servicio de Endocrinología y Nutrición, Hospital Clínic,
Universitat de Barcelona, Barcelona, Spain. Email: amdehol@clinic.ub.es
SOURCE
Endocrinologia y Nutricion (2013) 60:10 (604-606). Date of Publication:
December 2013
ISSN
1575-0922
1579-2021 (electronic)
BOOK PUBLISHER
Elsevier Doyma, Traversa de Gracia 17-21, Barcelona, Spain.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
autoimmune disease (side effect, side effect)
hypophysitis (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
human
letter
CAS REGISTRY NUMBERS
ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Immunology, Serology and Transplantation (26)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
Spanish
EMBASE ACCESSION NUMBER
2013768633
MEDLINE PMID
23607982 (http://www.ncbi.nlm.nih.gov/pubmed/23607982)
PUI
L52545819
DOI
10.1016/j.endonu.2013.01.007
FULL TEXT LINK
http://dx.doi.org/10.1016/j.endonu.2013.01.007
COPYRIGHT
Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 28
TITLE
Ipilimumab-induced endocrinopathies: When to start corticosteroids (or not)
AUTHOR NAMES
Corsello S.M.
Salvatori R.
Barnabei A.
De Vecchis L.
Marchetti P.
Torino F.
AUTHOR ADDRESSES
(Corsello S.M., corsello.sm@mclink.it) Endocrinology Unit, Università
Cattolica, Rome, Italy.
(Salvatori R.) Pituitary Center, Division of Endocrinology, Johns Hopkins
University School of Medicine, Baltimore MD, United States.
(Barnabei A.) Endocrinology Unit, Regina Elena National Cancer Institute,
Rome, Italy.
(De Vecchis L.; Torino F.) Department of Systems Medicine, Tor Vergata
University of Rome, Rome, Italy.
(Marchetti P.) Department of Clinical and Molecular Medicine, Sant'Andrea
Hospital, Sapienza University of Rome, Rome, Italy.
CORRESPONDENCE ADDRESS
S.M. Corsello, Endocrinology Unit, Università Cattolica, Rome, Italy. Email:
corsello.sm@mclink.it
SOURCE
Cancer Chemotherapy and Pharmacology (2013) 72:2 (489-490). Date of
Publication: August 2013
ISSN
0344-5704
1432-0843 (electronic)
BOOK PUBLISHER
Springer Verlag, Tiergartenstrasse 17, Heidelberg, Germany.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
ipilimumab (adverse drug reaction)
EMTREE DRUG INDEX TERMS
dexamethasone (drug dose, drug therapy, oral drug administration)
methylprednisolone (drug therapy, intravenous drug administration)
prednisone (drug therapy, oral drug administration)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
endocrine disease (drug therapy, side effect, drug therapy, prevention, side
effect)
EMTREE MEDICAL INDEX TERMS
adrenal insufficiency (prevention, side effect)
cancer chemotherapy
corticosteroid therapy
diarrhea (side effect)
drug dose reduction
drug eruption (side effect)
drug indication
drug megadose
drug monitoring
drug safety
drug withdrawal
endocrine ophthalmopathy (side effect)
hormone substitution
human
hypophysitis (drug therapy, prevention, side effect)
hypopituitarism (prevention)
letter
priority journal
side effect (side effect)
thyroid disease (side effect)
thyroid function test
thyroiditis (side effect)
CAS REGISTRY NUMBERS
dexamethasone (50-02-2)
ipilimumab (477202-00-9)
methylprednisolone (6923-42-8, 83-43-2)
prednisone (53-03-2)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Cancer (16)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2013480638
MEDLINE PMID
23779068 (http://www.ncbi.nlm.nih.gov/pubmed/23779068)
PUI
L52639604
DOI
10.1007/s00280-013-2213-y
FULL TEXT LINK
http://dx.doi.org/10.1007/s00280-013-2213-y
COPYRIGHT
Copyright 2013 Elsevier B.V., All rights reserved.

RECORD 29
TITLE
Re: Drug-induced Graves disease From CTLA-4 receptor suppression
AUTHOR NAMES
Sohrab M.A.
Desai R.U.
Chambers C.B.
Lissner G.S.
AUTHOR ADDRESSES
(Sohrab M.A., mahsa-sohrab@fsm.northwestern.edu; Desai R.U.; Chambers C.B.;
Lissner G.S.) Department of Ophthalmology, Northwestern University, 645
North Michigan Avenue, Chicago, IL 60611, United States.
CORRESPONDENCE ADDRESS
M.A. Sohrab, Department of Ophthalmology, Northwestern University, 645 North
Michigan Avenue, Chicago, IL 60611, United States. Email:
mahsa-sohrab@fsm.northwestern.edu
SOURCE
Ophthalmic Plastic and Reconstructive Surgery (2013) 29:3 (239-240). Date of
Publication: May-June 2013
ISSN
0740-9303
1537-2677 (electronic)
BOOK PUBLISHER
Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327,
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
cytotoxic T lymphocyte antigen 4 (endogenous compound)
ipilimumab (adverse drug reaction, drug therapy)
EMTREE DRUG INDEX TERMS
e 1608
unclassified drug
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
drug induced disease
Graves disease (side effect, side effect)
EMTREE MEDICAL INDEX TERMS
endocrine ophthalmopathy
human
letter
metastatic melanoma (drug therapy)
priority journal
uvea melanoma
visual acuity
DRUG TRADE NAMES
e 1608
CAS REGISTRY NUMBERS
ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Ophthalmology (12)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2013436832
MEDLINE PMID
23652294 (http://www.ncbi.nlm.nih.gov/pubmed/23652294)
PUI
L369300266
DOI
10.1097/IOP.0b013e3182895795
FULL TEXT LINK
http://dx.doi.org/10.1097/IOP.0b013e3182895795
COPYRIGHT
Copyright 2014 Elsevier B.V., All rights reserved.

RECORD 30
TITLE
Reply Re: Drug-induced Graves disease from CTLA-4 receptor suppression
AUTHOR NAMES
Borodic G.E.
Hinkle D.M.
AUTHOR ADDRESSES
(Borodic G.E., borodic@aol.com; Hinkle D.M.) Harvard Medical School, Quincy,
MA 02169, United States.
CORRESPONDENCE ADDRESS
G.E. Borodic, Harvard Medical School, Quincy, MA 02169, United States.
Email: borodic@aol.com
SOURCE
Ophthalmic Plastic and Reconstructive Surgery (2013) 29:3 (241). Date of
Publication: May-June 2013
ISSN
0740-9303
1537-2677 (electronic)
BOOK PUBLISHER
Lippincott Williams and Wilkins, 530 Walnut Street,P O Box 327,
Philadelphia, United States.
EMTREE DRUG INDEX TERMS (MAJOR FOCUS)
cytotoxic T lymphocyte antigen 4 (endogenous compound)
ipilimumab (adverse drug reaction)
T lymphocyte receptor (endogenous compound)
EMTREE DRUG INDEX TERMS
CD40 antigen (endogenous compound)
non receptor protein tyrosine phosphatase 22 (endogenous compound)
thyroglobulin antibody (endogenous compound)
thyroid hormone (endogenous compound)
EMTREE MEDICAL INDEX TERMS (MAJOR FOCUS)
drug induced disease
endocrine ophthalmopathy (side effect, etiology, side effect)
gene repression
EMTREE MEDICAL INDEX TERMS
gene mutation
genetic association
genetic polymorphism
human
insulin dependent diabetes mellitus
letter
primary biliary cirrhosis
priority journal
T lymphocyte activation
CAS REGISTRY NUMBERS
ipilimumab (477202-00-9)
EMBASE CLASSIFICATIONS
Endocrinology (3)
Ophthalmology (12)
Immunology, Serology and Transplantation (26)
Drug Literature Index (37)
Adverse Reactions Titles (38)
LANGUAGE OF ARTICLE
English
EMBASE ACCESSION NUMBER
2013436833
MEDLINE PMID
23652295 (http://www.ncbi.nlm.nih.gov/pubmed/23652295)
PUI
L369300267
DOI
10.1097/IOP.0b013e31828957c3
FULL TEXT LINK
http://dx.doi.org/10.1097/IOP.0b013e31828957c3
COPYRIGHT
Copyright 2014 Elsevier B.V., All rights reserved.

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