Now showing items 411-420 of 444
Engineering Disulfide Cross‐Links in RNA Via Air Oxidation
(Oxford University PressWiley Periodicals, Inc., 2000-02)
This unit presents protocols for the synthesis of alkylthiol‐modified ribonucleosides, their incorporation into synthetic RNA, and the formation of intramolecular disulfide bonds in RNA by air oxidation. The disulfide bonds ...
Introduction to the Synthesis and Purification of Oligonucleotides
(Applied BiosystemsWiley Periodicals, Inc., 2000-02)
Modern nucleic acid synthesizers utilize phosphite triester chemistries that employ stable phosphoramidite monomers to build a growing polymer. These robust reactions allow easy generation of specific oligodeoxyribo‐ and ...
A phase II study of chloroquinoxaline sulfonamide (CQS) in patients with metastatic colorectal carcinoma (MCRC)
(Kluwer Academic Publishers; Springer Science + Business Media, Inc, 2006-01-28)
Purpose: Phase II multicenter study investigated the efficacy and toxicity of the novel halogenated derivative of sulfaquixonaline Chloroquinoxaline Sulfonamide (CQS) in metastatic colorectal cancer. Experimental design: ...
Proteomic analysis of estrogen response of premalignant human breast cells using a 2-D liquid separation/mass mapping technique
(WILEY-VCH Verlag, 2006-07)
A 2-D liquid-phase separation method based on chromatofocusing and nonporous silica RP-HPLC followed by ESI-TOF-MS was used to analyze proteins in whole cell lysates from estrogen-treated and untreated premalignant, ...
Determination of Α-helix and Β-sheet stability in the solid state: A solid-state NMR investigation of poly( L -alanine)
(Wiley Subscription Services, Inc., A Wiley Company, 2002-08-15)
The relative stability of Α-helix and Β-sheet secondary structure in the solid state was investigated using poly( L -alanine) (PLA) as a model system. Protein folding and stability has been well studied in solution, but ...
Development of Biomimetic Interfaces and Their Applications.
(2009)
This dissertation details strategies for the fabrication of sophisticated biofunctional materials and their use in biomedical and biotechnological application. These unique biointerfaces were designed by integrating ...
Characterization of Industrial and Biological Complex Fluids Using Confocal Microscopy.
(2008)
Complex fluids are materials that respond to applied stresses in a way that is
intermediate between that of a purely viscous fluid or a fully elastic solid. The
characterization of material properties depends upon the ...
Silica Precipitation from Analcime Dissolution.
(2009)
Pure monosilicic acid solutions mimic the precipitation of silica dissolved from analcime in HCl. Thus, mineral dissolution and silica precipitation are decoupled and pure monosilicic acid solutions were used to study the ...
Atmospheric chemistry of cyclohexanone: UV spectrum and kinetics of reaction with chlorine atoms
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05)
Absolute and relative rate techniques were used to study the reactivity of Cl atoms with cyclohexanone in 6 Torr of argon or 800–950 Torr of N 2 at 295 ± 2 K. The absolute rate experiments gave k (Cl + cyclohexanone) = ...