Now showing items 71-80 of 444
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
(Springer-Verlag, 2006-07)
Purpose : This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated ...
Modeling ssDNA electrophoretic migration with band broadening in an entangled or cross-linked network
(WILEY-VCH Verlag, 2007-08)
We use a coarse-grained model proposed by Graham and Larson based on the temporary network model by Schieber et al.. [1] to simulate the electrophoretic motion of ssDNA and corresponding band broadening due to dispersion. ...
A Base‐Labile Protecting Group (Fluorenylmethoxycarbonyl) for the 5′‐Hydroxy Function of Nucleosides
(Wiley Periodicals, Inc.IRL Press, 2000-02)
Many popular synthesis strategies look for appropriate 2′‐O‐protection methods to use in conjunction with 5′‐O‐trityl chemistry. In contrast, this unit describes the use of FMOC as a 5′‐protecting group in conjunction with ...
Preparation of 5′‐Silyl‐2′‐Orthoester Ribonucleosides for Use in Oligoribonucleotide Synthesis
(Wiley Periodicals, Inc., 2004-03)
The recent discovery that small interfering RNAs (siRNAs) induce gene suppression in mammalian cells has sparked tremendous interest in using siRNA‐based assays and high‐throughput screens to study gene function. As a ...
Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1,3-Dipolar Cycloaddition
(WILEY-VCH Verlag, 2008-10-22)
Precise nano- and microscale control of the architecture of biodegradable biomaterials is desirable for several biotechnological applications such as drug delivery, diagnostics, and medical imaging. Herein, we combine ...
Meixner Wavelet Transform: A Tool for Studying Stationary Discrete-Time Stochastic Processes
(Kluwer Academic Publishers-Plenum Publishers; MAIK “Nauka/Interperiodica” ; Springer Science+Business Media, 2003-02)
A general approach to analyzing discrete stochastic processes in the context of spectral analysis in the Laplace domain is considered. It is shown that a multichannel algorithm, which may be used for determining a discrete ...
Stepwise Solid‐Phase Synthesis of Nucleopeptides
(Wiley Periodicals, Inc.Academic Press, 2004-03)
Phosphodiester‐linked peptide‐oligonucleotide conjugates (nucleopeptides) are obtained by stepwise solid‐phase procedures. The peptide is first assembled on a suitably derivatized solid matrix and the oligonucleotide is ...
Phase II Trial of Docetaxel Chemotherapy in Patients with Incurable Adenocarcinoma of the Esophagus
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-02)
Background : Chemotherapy remains theprimary mode of treatment for metastaticcarcinoma of the esophagus. The efficacyof various chemotherapeutic regimens hasbeen studied predominantly in patients withsquamous cell carcinoma ...
Palladium‐Mediated C5 Substitution of Pyrimidine Nucleosides
(Wiley Periodicals, Inc.IRL Press, 2000-02)
One of the most efficient ways to link a reporter group to oligonucleotides is through the incorporation of a modified nucleoside during automated oligonucleotide synthesis. To be useful, it is important that the reporter ...