Now showing items 1-10 of 123
Hydrogen sulfide concentration in the milieu of the hydrated alanine dipeptide determines its polyproline II‐beta propensity: Main chain contribution to the energetic origin of the formation of amyloid
(John Wiley & Sons, Inc., 2020-07)
In view of the observation that the concentration of hydrogen sulfide in brains with Alzheimer’s disease (AD) is lower than that in normal brains and in line with our previous studies indicating that additional content in ...
On Demand Light‐Degradable Polymers Based on 9,10‐Dialkoxyanthracenes
(Wiley Periodicals, Inc., 2020-08)
Light induced degradation of polymers has drawn increasing interest due to the need for externally controllable modulation of materials properties. However, the portfolio of polymers, that undergo precisely controllable ...
Enantiomeric Discrimination by Surface- Enhanced Raman Scattering- Chiral Anisotropy of Chiral Nanostructured Gold Films
(Wiley Periodicals, Inc.Cambridge University Press, 2020-08-24)
A surface- enhanced Raman scattering- chiral anisotropy (SERS- ChA) effect is reported that combines chiral discrimination and surface Raman scattering enhancement on chiral nanostructured Au films (CNAFs) equipped in ...
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
(Wiley Periodicals, Inc., 2020-08-03)
Engineering polyketide synthases (PKS) to produce new metabolites requires an understanding of catalytic points of failure during substrate processing. Growing evidence indicates the thioesterase (TE) domain as a significant ...
Enzyme Scaffolds with Hierarchically Defined Properties via 3D Jet Writing
(Wiley Periodicals, Inc.Millersville, PA, 2020-09)
The immobilization of enzymes into polymer hydrogels is a versatile approach to improve their stability and utility in biotechnological and biomedical applications. However, these systems typically show limited enzyme ...
Mixed‐solvent molecular dynamics simulation‐based discovery of a putative allosteric site on regulator of G protein signaling 4
(John Wiley & Sons, Inc., 2021-11-15)
Regulator of G protein signaling 4 (RGS4) is an intracellular protein that binds to the Gα subunit ofheterotrimeric G proteins and aids in terminating G protein coupled receptor signaling. RGS4 has been implicated in pain, ...
Reformulating the permselectivity‐conductivity tradeoff relation in ion‐exchange membranes
(John Wiley & Sons, Inc., 2021-11-01)
Polymer membranes used in separation applications exhibit a tradeoff between permeability and selectivity. That is, membranes that are highly permeable tend to have low selectivity and vice versa. For ion‐exchange membranes ...
An improved Poisson‐Nernst‐Planck ion channel model and numerical studies on effects of boundary conditions, membrane charges, and bulk concentrations
(John Wiley & Sons, Inc., 2021-10-15)
In this paper, an improved Poisson‐Nernst‐Planck ion channel (PNPic) model is presented, along with its effective finite element solver and software package for an ion channel protein in a solution of multiple ionic species. ...