Now showing items 81-90 of 121
A Systematic Informatics Approach to Synthetic Chemistry
(2023)
The navigation of chemical space through synthesis is a core principle behind drug discovery. Traditional medicinal chemistry programs rely on a few, well-developed reactivities to create pharmacophore derivatives and ...
Data-Driven Modeling of Compressible Reacting Flow Using Hardware-Oriented Algorithms
(2022)
High-fidelity numerical simulations of combustion processes in next-generation hypersonic propulsion devices (including, but not limited to, rotating detonation engines and scramjets) play a crucial role in enabling robust ...
Understanding the Optical and Photophysical Properties of Organic and Hybrid Macromolecules and Polymers for Solar Cell Application
(2021)
Organic solar cell materials represent a better sustainable alternative relative to inorganic materials in terms of lower cost, ease of large-scale processing, better absorptivity, ease of tunability, and unique flexibility ...
Continuum-Scale Modeling of Rechargeable Batteries
(2020)
During the operation of a rechargeable battery, the electrochemical reactions occur at the interface between the electrolyte and the active material in the electrode. The electrochemical performance of such batteries is ...
Multiscale Modeling of Polymer-Colloid Interactions in Waterborne Coatings
(2021)
Formulations containing rheology modifying polymers and nanometer sized colloids have widespread
use in pharmaceuticals, personal care products, and waterborne coatings. When combined
in solution, hydrophobic endcaps of ...
Developing and Applying Microdroplet Co-Cultivation Technology for Elucidating Bacterial Interspecies Interactions in the Human Vaginal Microbiome
(2020)
The role of the human vaginal microbiome (HVM) has gained increased recognition
due to recent technological advancements that helped link community composition
and women's health risks. However, the ecological roles of ...
Development of Modular, Droplet Microfluidic Workflows to Investigate Cellular Heterogeneity
(2023)
Cells exist in unique contexts within a population, but miniscule differences in their environment, epigenome, and cell cycle produce an assortment of observable characteristics in cells. Conventional cellular analysis ...
Application of Ultra-low Circulating Biomarkers and Single Cell Analysis from Solid Tumors with Single Molecule Resolution
(2020)
Circulating tumor cells (CTCs) and extracellular vesicles (EVs) carry tumor-derived cargo in the circulation and provide the potential for minimally invasive patient monitoring. These circulating biomarkers have both been ...
Innovations in Droplet Microfluidics for Enzyme Evolution
(2020)
High throughput screening (HTS) is a critical technology in discovery and process chemistry. Typically, HTS has relied on robotic handling of well plates of samples to rapidly perform and assess reactions, but novel ...
Engineering of Self-healing Adhesives and Polymeric Sensors with Stretchable Applications
(2020)
An ultra-fast self-healing adhesive (SHA) has been developed based on a reversible network of dynamic metal−ligand interactions which is strategically manipulated by activation energy control. The amorphous structure with ...