Now showing items 61-70 of 152
A test of the equal-environment assumption in twin studies of psychiatric illness
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1993-01)
The traditional twin method is predicated on the equal-environment assumption (EEA)—that monozygotic (MZ) and dizygotic (DZ) twins are equally correlated in their exposure to environmental events of etiologic importance ...
Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella
(Elsevier, 1993-04)
A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and TA1535. Mutagenicity ...
Localization of the ~12 kDa Mr discrepancy in gel migration of the mouse glucocorticoid receptor to the major phosphorylated cyanogen bromide fragment in the transactivating domain
(Elsevier, 1993-12)
The intact wild-type mouse glucocorticoid receptor has a theoretical molecular weight of ~86 kDa based on amino acid sequence, but on SDS-polyacrylamide gel electrophoresis it migrates as a protein of ~98 kDa. It is not ...
The stochastic SI model with recruitment and deaths I. comparison with the closed SIS model
(Elsevier, 1993)
We compare the stochastic and deterministic version of an SI model with recuitment, background deaths, and deaths due to the disease. For the stochastic version, analysis of the mean number of susceptibles, m, and infecteds, ...
Genetic Mapping and Evaluation of Candidate Genes for Spasmodic, a Neurological Mouse Mutation with Abnormal Startle Response
(Elsevier, 1993-08)
Spasmodic (spd) is a recessive mouse mutation characterized by a prolonged righting reflex, fine motor tremor, leg clasping, and stiffness. Using an intersubspecific backcross that segregates spd, we placed spd on Chr 11 ...
Autoradiography-based, three-dimensional calculation of dose rate for murine, human-tumor xenografts
(Elsevier, 1993-11)
A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. ...
Retroviruses: delivery vehicle to the liver
(Elsevier, 1993-02)
Liver-directed gene therapy holds great promise for the treatment of inherited metabolic disease. Two strategies have emerged. Ex vivo gene therapy involves the transplantation of autologous hepatocytes transduced with ...
Effect of hydrogen peroxide on the biodegradation of PCBs in anaerobically dechlorinated river sediments
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-12)
The ability to initiate aerobic conditions in dechlorinated anaerobic sediments was tested using hydrogen peroxide as an oxygenation agent. Hydrogen peroxide additions to the sediment induced aerobic polychlorinated biphenyl ...
The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein?
(Elsevier, 1993-09)
In many cells, the glucocorticoid receptor undergoes rapid steroid-mediated translocation from the cytoplasm to the nucleus, and this receptor is an excellent model for studying the mechanism of targeted protein movement ...