Now showing items 31-40 of 152
Protooncogene-encoded protein kinases in interleukin-2 signal transduction
(Elsevier, 1993-10)
Protooncogenes are the normal forms of cellular genes that when altered in their expression or coding sequences can contribute to neoplastic transformation. As these genes often are important for normal cellular growth ...
Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2
(Elsevier, 1993-01)
Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA ...
Genetic and Physical Map of 11 Short Tandem Repeat Polymorphisms on Human Chromosome 6
(Elsevier, 1993-01)
A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S253. For the region spanned ...
Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20
(Elsevier, 1993-06)
The human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation ...
Loss of antibody productivity is highly reproducible in multiple hybridoma subclones
(Wiley Subscription Services, Inc., A Wiley Company, 1993-06-20)
An immunoglobulin G (IgG 2b ) producing hybridoma cell line (S3H5/Γ2bA2) was cloned and subcloned. Twenty subclones were grown in parallel while being adapted in a stepwise fashion to serum-free medium. Following adaptation ...
Lactate Oxidation for the Detection of Mitochondrial Dysfunction in Human Skin Fibroblasts
(Elsevier, 1993-05-01)
To screen fibroblasts for defects in lactate/pyruvate oxidation, cells were grown to confluence in 25-cm2 flasks, rinsed, and incubated in glucose-free media containing 25 [mu]M L-lactate and 0.1 [mu]Ci [D,L-1-14C]lactate. ...
Inhibition of binding of phospholipase CΓ1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides
(Blackwell Publishing Ltd, 1993-09)
Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model
(Elsevier, 1993-09-15)
Streptococcus gordonii, a member of the human indigenous oral microflora, colonizes smooth tooth surfaces and contributes to dental plaque formation. Although it is not recognized as being a cariogenic pathogen, it may ...