Now showing items 821-830 of 898
Functional Analysis of Protein S-Palmitoylation Enzymes.
(2015)
Protein S-palmitoylation is a dynamic, hydrophobic, post-translational modification of cysteine residues that is required for the spatiotemporal organization of hundreds of proteins. In turn, protein palmitoylation contributes ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
Activation of G Protein-Coupled Receptors and Heterotrimeric G Proteins.
(2013)
G protein-coupled receptors (GPCRs) are an important class of cell-surface transmembrane receptors that pass an activation signal to the interior of the cell through heterotrimeric G proteins. In this work, we study the ...
Investigation of Apoptosis and Metabolism as Mechanisms of Trichloroethylene Toxicity During Pregnancy
(2020)
Trichloroethylene (TCE), an organic solvent with multiple industrial uses, is associated with adverse pregnancy outcomes in epidemiological studies. In timed-pregnant Wistar rats, TCE exposure reduces fetal weight. ...
Vacuolar Proteases of Saccharomyces cerevisiae: Characterization of an Overlooked Homolog Leads to New Functional Insights
(2017)
Hydrolysis within the vacuole in yeast and lysosome in mammals is required for the degradation and recycling of a vast array of substrates. In humans, defects in lysosomal hydrolysis and efflux contribute to a class of ...
Investigating Mechanisms of Immune Evasion by HIV-1 Vpr.
(2016)
Human immunodeficiency virus (HIV) causes significant morbidity and mortality worldwide, yet several HIV proteins have not been fully characterized. The development of cell culture models to study retroviruses has accelerated ...
Structural Studies of RNA Packaging by Phlebovirus Nucleocapsid Proteins and RNA Capping by Flavivirus Methyltransferases.
(2012)
Arboviruses are maintained in nature through a complex life cycle involving blood-sucking insects and susceptible vertebrate hosts. Arboviruses have evolved mechanisms to conceal their RNA genomes from the cellular antiviral ...
Integrative Analysis Frameworks for Improved Peptide and Protein Identifications from Tandem Mass Spectrometry Data.
(2015)
Tandem mass spectrometry (MS/MS) followed by database search is the method of choice for high throughput protein identification in modern proteomic studies. Database searching methods employ spectral matching algorithms ...
Identifying, Modeling and Targeting IGF-II Overexpression in the Adrenocortical Carcinoma.
(2012)
Insulin-like growth factor-II (IGF-II) is a mitogenic growth factor that elicits cellular effects primarily through its downstream signaling pathway. The IGF signaling pathway is a critical cellular system for stimulating ...
Targeting Branched Chain Amino Acid Metabolism in Tumor Microenvironment
(2020)
Branched Chain amino acids (BCAAs) play an essential role in cell metabolism supplying both carbon and nitrogen in pancreatic cancers, and their increased levels have been associated with increased risk of pancreatic ductal ...