Now showing items 11-20 of 212
Highlights of B/D‐HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics
(Wiley Periodicals, Inc., 2014-05)
Effects of hydroxyurea on CNV induction in the mouse germline
(John Wiley & Sons, Inc., 2018-10)
Rareâ variant association tests in longitudinal studies, with an application to the Multiâ Ethnic Study of Atherosclerosis (MESA)
(Wiley Periodicals, Inc.Springer New York, 2017-12)
Over the past few years, an increasing number of studies have identified rare variants that contribute to trait heritability. Due to the extreme rarity of some individual variants, geneâ based association tests have been ...
Early events of Bacillus anthracis germination identified by time-course quantitative proteomics
(WILEY-VCH Verlag, 2006-10)
Germination of Bacillus anthracis spores involves rehydration of the spore interior and rapid degradation of several of the protective layers, including the spore coat. Here, we examine the temporal changes that occur ...
Use of inverse PCR to amplify and sequence breakpoints of HPRT deletion and translocation mutations
(John Wiley & Sons, Inc., 2002)
Deletion and translocation mutations have been shown to play a significant role in the genesis of many cancers. The hprt gene located at Xq26 is a frequently used marker gene in human mutational studies. In an attempt ...
The Role of Environmental Heterogeneity in Meta‐Analysis of Gene–Environment Interactions With Quantitative Traits
(Wiley, 2014-07)
With challenges in data harmonization and environmental heterogeneity across various data sources, meta‐analysis of gene–environment interaction studies can often involve subtle statistical issues. In this paper, we study ...
Biological Network Exploration with Cytoscape 3
(Association for the Advancement of Artificial IntelligenceWiley Periodicals, Inc., 2014-09)
Cytoscape is one of the most popular open‐source software tools for the visual exploration of biomedical networks composed of protein, gene, and other types of interactions. It offers researchers a versatile and interactive ...
Genome‐Wide Family‐Based Linkage Analysis of Exome Chip Variants and Cardiometabolic Risk
(Wiley Periodicals, Inc., 2014-04)
Linkage analysis of complex traits has had limited success in identifying trait‐influencing loci. Recently, coding variants have been implicated as the basis for some biomedical associations. We tested whether coding ...
Methods for meta‐analysis of multiple traits using GWAS summary statistics
(Oxford University PressWiley Periodicals, Inc., 2018-03)
Genome‐wide association studies (GWAS) for complex diseases have focused primarily on single‐trait analyses for disease status and disease‐related quantitative traits. For example, GWAS on risk factors for coronary artery ...
Understanding the accuracy of statistical haplotype inference with sequence data of known phase
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Statistical methods for haplotype inference from multi-site genotypes of unrelated individuals have important application in association studies and population genetics. Understanding the factors that affect the accuracy ...